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Zinc in PDB 1g53: Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide

Enzymatic activity of Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide

All present enzymatic activity of Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide, PDB code: 1g53 was solved by C.-Y.Kim, J.S.Chang, J.B.Doyon, T.T.Baird Jr., C.A.Fierke, A.Jain, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.94
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.720, 41.970, 72.730, 90.00, 104.57, 90.00
R / Rfree (%) 19.8 / 26.2

Other elements in 1g53:

The structure of Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide (pdb code 1g53). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide, PDB code: 1g53:

Zinc binding site 1 out of 1 in 1g53

Go back to Zinc Binding Sites List in 1g53
Zinc binding site 1 out of 1 in the Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase II Complexed with 4-(Aminosulfonyl)-N-[(2,6- Difluorophenyl)Methyl]-Benzamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:13.3
occ:1.00
 NP2 A:F6B555 1.7 15.2 1.0
NE2 A:HIS94 1.8 16.0 1.0
NE2 A:HIS96 1.9 14.9 1.0
ND1 A:HIS119 2.0 9.9 1.0
CD2 A:HIS94 2.8 3.5 1.0
S11 A:F6B555 2.8 8.4 1.0
CE1 A:HIS94 2.8 4.2 1.0
CE1 A:HIS96 2.9 7.1 1.0
CE1 A:HIS119 2.9 5.2 1.0
CD2 A:HIS96 3.0 6.1 1.0
O13 A:F6B555 3.1 8.8 1.0
CG A:HIS119 3.2 7.4 1.0
CB A:HIS119 3.6 3.2 1.0
OG1 A:THR199 3.9 8.4 1.0
CG A:HIS94 3.9 10.5 1.0
ND1 A:HIS94 3.9 9.5 1.0
C03 A:F6B555 4.0 10.3 1.0
OE1 A:GLU106 4.0 13.6 1.0
O14 A:F6B555 4.0 12.9 1.0
ND1 A:HIS96 4.0 8.2 1.0
CG A:HIS96 4.1 8.4 1.0
NE2 A:HIS119 4.1 6.2 1.0
CD2 A:HIS119 4.2 7.4 1.0
O A:HOH395 4.5 34.9 1.0
C02 A:F6B555 4.6 8.1 1.0
C04 A:F6B555 4.8 7.9 1.0
CD A:GLU106 5.0 9.2 1.0

Reference:

C.-Y.Kim, J.S.Chang, J.B.Doyon, T.T.Baird Jr., C.A.Fierke, A.Jain, D.W.Christianson. Contribution of Flourine to Protein-Ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II J.Am.Chem.Soc. V. 122 12125 2000.
ISSN: ISSN 0002-7863
DOI: 10.1021/JA002627N
Page generated: Sun Oct 13 01:21:04 2024

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