Zinc in PDB 1fss: Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II

All present enzymatic activity of Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II:
3.1.1.7;

The structure of Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II, PDB code: 1fss was solved by M.Harel, G.J.Kleywegt, I.Silman, J.L.Sussman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 3.00
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	87.390, 115.000, 67.470, 90.00, 90.00, 90.00
R / Rfree (%)	23 / 31

The binding sites of Zinc atom in the Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II (pdb code 1fss). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II, PDB code: 1fss:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:19.8 occ:1.00 OE2 A:GLU350 2.5 26.1 1.0 OE1 A:GLU350 2.6 26.1 1.0 CD A:GLU350 2.9 26.1 1.0 CG A:GLU350 4.4 26.1 1.0

Zinc binding site 2 out of 2 in the Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Acetylcholinesterase (E.C. 3.1.1.7) Complexed with Fasciculin-II within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:19.2 occ:1.00 OE1 A:GLU49 2.5 40.0 1.0 OE2 A:GLU49 2.6 40.0 1.0 CD A:GLU49 2.9 40.0 1.0 CG A:GLU49 4.3 40.0 1.0 CD A:PRO50 4.7 12.7 1.0 CB A:GLU49 4.9 40.0 1.0

M.Harel, G.J.Kleywegt, R.B.Ravelli, I.Silman, J.L.Sussman. Crystal Structure of An Acetylcholinesterase-Fasciculin Complex: Interaction of A Three-Fingered Toxin From Snake Venom with Its Target. Structure V. 3 1355 1995.
ISSN: ISSN 0969-2126
PubMed: 8747462
DOI: 10.1016/S0969-2126(01)00273-8