Zinc in PDB 1dww: Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin

All present enzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin:
1.14.13.39;

The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin, PDB code: 1dww was solved by B.R.Crane, A.S.Arvai, E.D.Getzoff, D.J.Stuehr, J.A.Tainer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.35
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	212.980, 212.980, 114.200, 90.00, 90.00, 120.00
R / Rfree (%)	24.9 / 28.8

The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin also contains other interesting chemical elements:

Iron

(Fe)

2 atoms

The binding sites of Zinc atom in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin (pdb code 1dww). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin, PDB code: 1dww:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn903 b:33.3 occ:0.50 SG A:CYS109 2.2 43.1 1.0 SG A:CYS104 2.2 53.3 1.0 CB A:CYS109 3.2 43.5 1.0 CB A:CYS104 3.3 62.6 1.0 CA A:CYS109 3.6 46.4 1.0 N A:LEU110 4.2 46.7 1.0 N A:GLY111 4.2 48.1 1.0 C A:CYS109 4.3 45.9 1.0 CA A:GLY111 4.7 47.0 1.0 CA A:CYS104 4.7 64.8 1.0 N A:CYS109 4.9 48.7 1.0 O A:SER108 4.9 51.5 1.0

Zinc binding site 2 out of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer N-Hydroxyarginine and Dihydrobiopterin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn903 b:37.0 occ:0.50 SG B:CYS104 2.2 53.8 1.0 SG B:CYS109 2.3 47.5 1.0 CB B:CYS104 3.3 65.9 1.0 CB B:CYS109 3.4 49.2 1.0 CA B:CYS109 3.8 52.0 1.0 N B:GLY111 4.3 48.8 1.0 N B:LEU110 4.3 51.3 1.0 C B:CYS109 4.5 50.6 1.0 CA B:GLY111 4.7 47.0 1.0 CA B:CYS104 4.7 68.8 1.0 O B:SER108 5.0 57.7 1.0

B.R.Crane, A.S.Arvai, S.Ghosh, E.D.Getzoff, D.J.Stuehr, J.A.Tainer. Structures of the N(Omega)-Hydroxy-L-Arginine Complex of Inducible Nitric Oxide Synthase Oxygenase Dimer with Active Andinactive Pterins Biochemistry V. 39 4608 2000.
ISSN: ISSN 0006-2960
PubMed: 10769116
DOI: 10.1021/BI992409A