Zinc in PDB 1btg: Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound

The structure of Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound, PDB code: 1btg was solved by D.R.Holland, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.50
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	109.800, 93.900, 58.900, 90.00, 123.10, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Zinc atom in the Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound (pdb code 1btg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound, PDB code: 1btg:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn902 b:42.2 occ:1.00 O B:HOH962 1.9 41.6 1.0 O B:HOH961 1.9 42.4 1.0 OD1 B:ASP105 2.0 19.9 1.0 NE2 B:HIS84 2.1 30.4 1.0 CE1 B:HIS84 3.0 28.5 1.0 CG B:ASP105 3.1 20.3 1.0 CD2 B:HIS84 3.1 30.0 1.0 OD2 B:ASP105 3.3 22.0 1.0 ND1 B:HIS84 4.1 27.9 1.0 CG B:HIS84 4.2 27.4 1.0 OG1 B:THR82 4.3 21.3 1.0 CB B:ASP105 4.4 14.8 1.0 NH2 B:ARG103 4.5 80.0 1.0 CA B:ASP105 4.8 14.5 1.0 CB B:THR82 5.0 15.6 1.0

Zinc binding site 2 out of 3 in the Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn900 b:36.9 occ:1.00 O C:HOH959 1.8 33.4 1.0 O C:HOH958 2.1 36.1 1.0 NE2 C:HIS84 2.1 28.1 1.0 OD1 C:ASP105 2.4 20.6 1.0 CE1 C:HIS84 3.0 28.2 1.0 CD2 C:HIS84 3.1 26.7 1.0 CG C:ASP105 3.5 23.3 1.0 ZN C:ZN901 3.5 30.7 1.0 OD2 C:ASP105 3.8 25.1 1.0 ND1 C:HIS84 4.1 29.4 1.0 CG C:HIS84 4.2 26.6 1.0 O C:HOH960 4.7 38.7 1.0 CB C:ASP105 4.7 6.2 1.0 CG2 C:THR82 4.7 18.8 1.0 CA C:ASP105 4.7 7.4 1.0 O C:HOH950 4.8 19.0 1.0 N C:ASP105 4.8 13.6 1.0

Zinc binding site 3 out of 3 in the Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Beta Nerve Growth Factor at 2.5 A Resolution in C2 Space Group with Zn Ions Bound within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn901 b:30.7 occ:1.00 OD2 C:ASP105 1.9 25.1 1.0 O C:HOH960 2.3 38.7 1.0 O C:HOH959 2.4 33.4 1.0 CG C:ASP105 2.7 23.3 1.0 OD1 C:ASP105 3.1 20.6 1.0 ZN C:ZN900 3.5 36.9 1.0 O C:HOH958 3.8 36.1 1.0 CE C:LYS57 3.9 11.9 1.0 CB C:ASP105 4.1 6.2 1.0 NZ C:LYS57 4.2 18.0 1.0 CD C:LYS57 4.4 6.7 1.0 CG2 C:THR82 4.6 18.8 1.0 O C:HOH950 4.7 19.0 1.0 CB C:LYS57 4.9 16.3 1.0

D.R.Holland, L.S.Cousens, W.Meng, B.W.Matthews. Nerve Growth Factor in Different Crystal Forms Displays Structural Flexibility and Reveals Zinc Binding Sites. J.Mol.Biol. V. 239 385 1994.
ISSN: ISSN 0022-2836
PubMed: 8201620
DOI: 10.1006/JMBI.1994.1380