Zinc in PDB 1aw5: 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae

All present enzymatic activity of 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae:
4.2.1.24;

The structure of 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae, PDB code: 1aw5 was solved by P.T.Erskine, J.B.Cooper, S.P.Wood, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	6.00 / 2.30
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	102.500, 102.500, 168.300, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Zinc atom in the 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae (pdb code 1aw5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae, PDB code: 1aw5:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:0.4 occ:1.00 SG A:CYS143 2.0 0.3 1.0 SG A:CYS133 2.1 0.2 1.0 SG A:CYS135 2.3 0.3 1.0 CB A:CYS135 2.9 0.0 1.0 CB A:CYS133 3.1 0.1 1.0 CB A:CYS143 3.4 0.5 1.0 N A:CYS135 3.7 0.3 1.0 CA A:CYS135 3.9 0.2 1.0 CA A:CYS143 3.9 0.1 1.0 O A:SER179 4.0 0.5 1.0 O A:HOH773 4.1 0.8 1.0 O A:HOH669 4.4 0.3 1.0 N A:LEU134 4.4 0.3 1.0 CA A:CYS133 4.5 0.3 1.0 O A:HOH604 4.6 0.3 1.0 N A:CYS143 4.7 0.4 1.0 OG A:SER179 4.7 0.2 1.0 C A:SER179 4.8 0.1 1.0 C A:CYS133 4.9 0.4 1.0 CA A:ASP180 4.9 0.2 1.0 C A:LEU134 4.9 0.2 1.0

Zinc binding site 2 out of 2 in the 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of 5-Aminolevulinate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:0.7 occ:1.00 SG A:CYS234 2.3 0.6 1.0 CD2 A:HIS142 2.9 0.5 1.0 NE2 A:HIS142 3.5 0.8 1.0 CG A:HIS142 3.6 1.2 1.0 CB A:CYS234 3.6 0.2 1.0 O A:HOH760 4.0 0.5 1.0 CA A:HIS142 4.1 0.2 1.0 CB A:HIS142 4.2 0.6 1.0 CE1 A:HIS142 4.4 1.6 1.0 ND1 A:HIS142 4.4 0.6 1.0 N A:CYS234 4.6 0.5 1.0 O A:GLY141 4.6 0.5 1.0 CA A:CYS234 4.8 2.0 1.0 N A:CYS143 4.8 0.4 1.0

P.T.Erskine, N.Senior, S.Awan, R.Lambert, G.Lewis, I.J.Tickle, M.Sarwar, P.Spencer, P.Thomas, M.J.Warren, P.M.Shoolingin-Jordan, S.P.Wood, J.B.Cooper. X-Ray Structure of 5-Aminolaevulinate Dehydratase, A Hybrid Aldolase. Nat.Struct.Biol. V. 4 1025 1997.
ISSN: ISSN 1072-8368
PubMed: 9406553
DOI: 10.1038/NSB1297-1025