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Zinc in PDB 12ca: Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121

Enzymatic activity of Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121

All present enzymatic activity of Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121:
4.2.1.1;

Protein crystallography data

The structure of Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121, PDB code: 12ca was solved by S.K.Nair, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) N/A / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.700, 41.700, 73.000, 90.00, 104.60, 90.00
R / Rfree (%) n/a / n/a

Other elements in 12ca:

The structure of Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121 also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121 (pdb code 12ca). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121, PDB code: 12ca:

Zinc binding site 1 out of 1 in 12ca

Go back to Zinc Binding Sites List in 12ca
Zinc binding site 1 out of 1 in the Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:5.7
occ:1.00
ND1 A:HIS119 2.1 4.4 1.0
NE2 A:HIS96 2.1 4.1 1.0
NE2 A:HIS94 2.5 5.6 1.0
CE1 A:HIS119 2.9 4.5 1.0
O A:HOH350 3.0 10.5 1.0
CD2 A:HIS96 3.0 4.2 1.0
CD2 A:HIS94 3.2 5.6 1.0
CE1 A:HIS96 3.2 4.2 1.0
CG A:HIS119 3.2 4.6 1.0
CE1 A:HIS94 3.7 5.7 1.0
OG1 A:THR199 3.7 7.4 1.0
CB A:HIS119 3.7 4.5 1.0
OE1 A:GLU106 3.9 5.4 1.0
NE2 A:HIS119 4.1 4.6 1.0
CG A:HIS96 4.2 4.3 1.0
ND1 A:HIS96 4.3 4.2 1.0
CD2 A:HIS119 4.3 4.5 1.0
CG A:HIS94 4.5 5.7 1.0
O A:HOH344 4.5 23.2 1.0
ND1 A:HIS94 4.6 5.7 1.0
CD A:GLU106 4.9 5.5 1.0

Reference:

S.K.Nair, T.L.Calderone, D.W.Christianson, C.A.Fierke. Altering the Mouth of A Hydrophobic Pocket. Structure and Kinetics of Human Carbonic Anhydrase II Mutants at Residue Val-121. J.Biol.Chem. V. 266 17320 1991.
ISSN: ISSN 0021-9258
PubMed: 1910042
Page generated: Wed Dec 16 02:44:19 2020

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