Zinc in PDB 9hju: Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna

All present enzymatic activity of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna:
2.3.2.27; 2.7.9.3;

The binding sites of Zinc atom in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna (pdb code 9hju). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna, PDB code: 9hju:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:65.6 occ:1.00 NE2 A:HIS104 2.0 21.3 1.0 NE2 A:HIS100 2.0 39.0 1.0 SG A:CYS84 2.3 51.3 1.0 SG A:CYS87 2.3 62.6 1.0 HD2 A:HIS100 2.4 34.9 1.0 CD2 A:HIS100 2.5 36.3 1.0 CD2 A:HIS104 2.7 25.4 1.0 HD2 A:HIS104 2.7 32.9 1.0 H A:CYS87 3.0 40.2 1.0 HB3 A:CYS84 3.1 35.6 1.0 CB A:CYS84 3.2 31.3 1.0 CE1 A:HIS104 3.2 25.1 1.0 HB2 A:CYS84 3.3 34.9 1.0 CE1 A:HIS100 3.3 34.6 1.0 HB3 A:CYS87 3.3 40.3 1.0 CB A:CYS87 3.4 42.8 1.0 HE1 A:HIS104 3.6 31.9 1.0 HE1 A:HIS100 3.7 34.3 1.0 N A:CYS87 3.7 39.7 1.0 HB2 A:TYR86 3.8 38.5 1.0 CG A:HIS100 3.8 26.9 1.0 CG A:HIS104 4.0 20.0 1.0 CA A:CYS87 4.1 37.2 1.0 HB3 A:ARG89 4.1 33.4 1.0 ND1 A:HIS100 4.1 29.5 1.0 H A:TYR86 4.2 38.4 1.0 ND1 A:HIS104 4.2 21.7 1.0 HB2 A:CYS87 4.2 40.3 1.0 HD2 A:TYR86 4.3 39.0 1.0 H A:ARG89 4.3 35.4 1.0 HE2 A:PHE91 4.5 35.4 1.0 H A:ALA88 4.6 35.7 1.0 CA A:CYS84 4.6 32.1 1.0 HA A:ARG101 4.7 34.8 1.0 CB A:TYR86 4.7 35.2 1.0 HB2 A:ARG89 4.8 33.1 1.0 C A:CYS87 4.8 29.9 1.0 C A:TYR86 4.9 34.7 1.0 N A:TYR86 4.9 33.4 1.0 CB A:ARG89 4.9 27.4 1.0 N A:ALA88 4.9 25.9 1.0 HA A:CYS87 5.0 39.0 1.0 HA A:CYS84 5.0 35.5 1.0 HD1 A:HIS100 5.0 33.6 1.0 HD1 A:HIS104 5.0 30.9 1.0

Zinc binding site 2 out of 5 in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn302 b:142.2 occ:1.00 NE2 A:HIS46 2.0 87.0 1.0 NE2 A:HIS41 2.0 88.7 1.0 SG A:CYS28 2.3 89.8 1.0 SG A:CYS23 2.3 103.5 1.0 CD2 A:HIS46 2.8 83.4 1.0 HB3 A:CYS28 2.9 91.5 1.0 HD2 A:HIS46 2.9 85.0 1.0 CD2 A:HIS41 2.9 81.3 1.0 HB3 A:CYS23 3.0 92.1 1.0 CE1 A:HIS41 3.0 84.6 1.0 CB A:CYS28 3.1 89.1 1.0 HD2 A:HIS41 3.1 80.8 1.0 CB A:CYS23 3.1 95.6 1.0 HB2 A:CYS23 3.1 92.0 1.0 CE1 A:HIS46 3.2 89.4 1.0 HE1 A:HIS41 3.3 81.3 1.0 HB2 A:CYS28 3.3 90.6 1.0 HE1 A:HIS46 3.5 86.5 1.0 HB3 A:MET25 4.0 104.8 1.0 HG1 A:THR30 4.0 77.9 1.0 CG A:HIS46 4.1 85.0 1.0 CG A:HIS41 4.1 77.5 1.0 ND1 A:HIS41 4.1 81.7 1.0 HG12 A:ILE42 4.1 82.2 1.0 ND1 A:HIS46 4.2 88.6 1.0 HA A:ILE42 4.5 81.5 1.0 CA A:CYS28 4.5 91.3 1.0 OG1 A:THR30 4.5 76.0 1.0 O A:CYS28 4.5 84.3 1.0 CA A:CYS23 4.6 92.0 1.0 HB2 A:GLN45 4.8 86.0 1.0 HD1 A:HIS41 4.9 81.0 1.0 HA A:CYS23 4.9 90.9 1.0 C A:CYS28 4.9 86.5 1.0 CB A:MET25 4.9 105.7 1.0 HA A:CYS28 4.9 91.1 1.0 HD1 A:HIS46 5.0 86.1 1.0

Zinc binding site 3 out of 5 in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn303 b:107.5 occ:1.00 HE2 A:HIS72 1.8 69.8 1.0 NE2 A:HIS72 2.0 76.0 1.0 NE2 A:HIS76 2.0 63.4 1.0 HD2 A:HIS72 2.2 68.4 1.0 CD2 A:HIS72 2.3 69.8 1.0 SG A:CYS54 2.3 73.9 1.0 SG A:CYS59 2.3 84.9 1.0 HD2 A:HIS76 2.5 63.4 1.0 CD2 A:HIS76 2.6 64.2 1.0 HB2 A:CYS54 2.7 74.7 1.0 CB A:CYS54 2.9 76.0 1.0 HB3 A:CYS54 2.9 74.4 1.0 HB2 A:CYS59 3.0 81.7 1.0 CE1 A:HIS72 3.1 69.8 1.0 CB A:CYS59 3.1 84.5 1.0 CE1 A:HIS76 3.3 58.7 1.0 HB3 A:CYS59 3.3 81.7 1.0 CG A:HIS72 3.4 60.5 1.0 HE1 A:HIS72 3.6 67.5 1.0 HE1 A:HIS76 3.7 62.3 1.0 ND1 A:HIS72 3.7 63.0 1.0 CG A:HIS76 3.9 57.3 1.0 HB2 A:ARG61 4.0 81.4 1.0 HB3 A:HIS56 4.0 75.5 1.0 HD3 A:ARG61 4.1 82.2 1.0 ND1 A:HIS76 4.2 59.0 1.0 HD2 A:HIS75 4.2 59.0 1.0 HB2 A:HIS56 4.2 75.1 1.0 HE1 A:PHE63 4.2 81.4 1.0 CA A:CYS54 4.4 76.8 1.0 HB3 A:HIS72 4.4 66.8 1.0 H A:HIS56 4.5 74.3 1.0 CB A:HIS72 4.5 58.4 1.0 CB A:HIS56 4.6 74.7 1.0 CA A:CYS59 4.6 85.2 1.0 HA A:CYS54 4.7 74.6 1.0 HG3 A:ARG61 4.7 82.0 1.0 H A:ARG61 4.8 82.0 1.0 HA A:CYS59 4.8 82.5 1.0 HZ A:PHE63 4.8 81.8 1.0 O A:HIS72 4.9 62.6 1.0 CB A:ARG61 4.9 79.9 1.0 CE1 A:PHE63 4.9 82.8 1.0 HD2 A:PRO55 4.9 70.7 1.0 CD A:ARG61 5.0 83.3 1.0 H A:CYS54 5.0 74.7 1.0

Zinc binding site 4 out of 5 in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn304 b:104.2 occ:1.00 HE2 A:HIS132 1.8 46.4 1.0 HD2 A:HIS132 2.0 46.7 1.0 NE2 A:HIS128 2.0 52.1 1.0 NE2 A:HIS132 2.0 55.8 1.0 CD2 A:HIS132 2.1 47.8 1.0 SG A:CYS115 2.3 39.1 1.0 SG A:CYS112 2.3 64.1 1.0 HD2 A:HIS128 2.6 40.4 1.0 CD2 A:HIS128 2.7 46.5 1.0 H A:CYS115 2.8 38.6 1.0 CE1 A:HIS132 3.2 57.3 1.0 HB3 A:CYS115 3.2 36.7 1.0 CE1 A:HIS128 3.2 46.2 1.0 CG A:HIS132 3.3 37.4 1.0 HB A:ILE114 3.3 38.5 1.0 CB A:CYS115 3.3 36.8 1.0 HB3 A:CYS112 3.3 39.2 1.0 CB A:CYS112 3.4 35.4 1.0 N A:CYS115 3.5 36.0 1.0 HB2 A:CYS112 3.5 40.1 1.0 HE1 A:HIS128 3.6 40.2 1.0 ND1 A:HIS132 3.8 49.0 1.0 HE1 A:HIS132 3.8 48.2 1.0 HB3 A:PHE117 3.8 37.8 1.0 CG A:HIS128 3.9 31.7 1.0 H A:ILE114 4.0 40.1 1.0 CA A:CYS115 4.0 34.6 1.0 HE1 A:MET129 4.1 44.0 1.0 HB2 A:CYS115 4.2 38.0 1.0 ND1 A:HIS128 4.2 34.2 1.0 CB A:ILE114 4.2 27.4 1.0 HE2 A:MET129 4.2 43.6 1.0 HB2 A:HIS132 4.3 46.7 1.0 H A:PHE117 4.4 39.0 1.0 CB A:HIS132 4.4 40.3 1.0 HG22 A:ILE114 4.5 39.8 1.0 HD13 A:ILE114 4.5 40.2 1.0 HD12 A:ILE114 4.5 39.9 1.0 C A:ILE114 4.5 39.5 1.0 CE A:MET129 4.6 46.0 1.0 C A:CYS115 4.7 31.8 1.0 N A:ILE114 4.7 33.7 1.0 H A:GLY116 4.7 37.3 1.0 CA A:ILE114 4.7 26.9 1.0 CB A:PHE117 4.7 32.4 1.0 CA A:CYS112 4.8 26.3 1.0 HA A:CYS115 4.8 37.6 1.0 HD2 A:PHE117 4.8 37.7 1.0 CG2 A:ILE114 4.9 40.4 1.0 HB2 A:PHE117 4.9 37.8 1.0 HB3 A:HIS132 4.9 46.8 1.0 N A:GLY116 4.9 31.8 1.0 CD1 A:ILE114 4.9 43.0 1.0 HD1 A:HIS128 5.0 38.0 1.0

Zinc binding site 5 out of 5 in the Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of 2X Zincore (SEPHS1:QRICH1) Binding to ZFP91 on Dna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn305 b:136.9 occ:1.00 NE2 A:HIS158 2.0 73.6 1.0 NE2 A:HIS163 2.1 69.5 1.0 SG A:CYS145 2.3 90.9 1.0 SG A:CYS142 2.3 87.1 1.0 HD2 A:HIS163 2.4 68.7 1.0 CD2 A:HIS163 2.5 67.5 1.0 CD2 A:HIS158 2.8 69.2 1.0 HD2 A:HIS158 2.9 65.5 1.0 H A:CYS145 2.9 79.8 1.0 CE1 A:HIS158 3.2 68.7 1.0 CE1 A:HIS163 3.3 71.9 1.0 CB A:CYS145 3.4 81.5 1.0 HB3 A:CYS145 3.5 80.5 1.0 HB2 A:LYS147 3.5 74.1 1.0 HE1 A:HIS158 3.5 64.9 1.0 HB A:ILE144 3.5 73.9 1.0 N A:CYS145 3.6 81.9 1.0 HE1 A:HIS163 3.7 70.4 1.0 CG A:HIS163 3.8 69.5 1.0 CB A:CYS142 3.8 74.3 1.0 HB2 A:CYS142 3.9 74.8 1.0 CA A:CYS145 4.0 80.1 1.0 CG A:HIS158 4.0 60.4 1.0 HB3 A:CYS142 4.1 75.1 1.0 ND1 A:HIS163 4.1 71.9 1.0 ND1 A:HIS158 4.2 65.9 1.0 HB2 A:CYS145 4.3 80.4 1.0 C A:CYS145 4.3 80.1 1.0 CB A:LYS147 4.4 75.7 1.0 H A:LYS147 4.5 74.0 1.0 CB A:ILE144 4.5 74.2 1.0 H A:ILE144 4.6 73.5 1.0 H A:GLY146 4.6 79.1 1.0 N A:GLY146 4.7 81.2 1.0 HB3 A:LYS147 4.7 73.5 1.0 C A:ILE144 4.7 76.2 1.0 HD3 A:LYS147 4.8 72.5 1.0 O A:CYS145 4.8 75.0 1.0 N A:LYS147 4.9 73.0 1.0 HA A:CYS145 4.9 79.6 1.0 HG22 A:ILE144 4.9 73.1 1.0 HD1 A:HIS163 5.0 69.8 1.0 HG12 A:ILE144 5.0 73.8 1.0 CA A:ILE144 5.0 73.4 1.0 HD1 A:HIS158 5.0 64.8 1.0

D.Bianchi, R.Borza, E.De Zan, G.Huelsz-Prince, S.Gregoricchio, M.Dekker, A.Fish, A.Mazouzi, L.Kroese, S.Linder, M.Hernandez Quiles, M.Vermeulen, P.Celie, P.Krimpenfort, J.Son, W.Zwart, L.Wessels, S.Nijman, A.Perrakis, T.Brummelkamp. Zincore, An Atypical Coregulator, Binds Zinc Finger Transcription Factors to Control Gene Expression Science 2025.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ADV2861