Zinc in PDB 9f3p: Cryo-Em Structure of the A946T MDA5-Dsrna Filament

All present enzymatic activity of Cryo-Em Structure of the A946T MDA5-Dsrna Filament:
3.6.4.13;

The binding sites of Zinc atom in the Cryo-Em Structure of the A946T MDA5-Dsrna Filament (pdb code 9f3p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of the A946T MDA5-Dsrna Filament, PDB code: 9f3p:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of the A946T MDA5-Dsrna Filament


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the A946T MDA5-Dsrna Filament within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:170.9 occ:1.00 SG A:CYS962 2.3 129.6 1.0 SG A:CYS910 2.3 130.3 1.0 SG A:CYS964 2.3 132.8 1.0 SG A:CYS907 2.3 127.8 1.0 H A:CYS910 2.9 130.3 1.0 HB3 A:CYS910 3.2 130.3 1.0 HB3 A:CYS962 3.2 129.6 1.0 HB3 A:CYS907 3.3 127.8 1.0 CB A:CYS910 3.3 130.3 1.0 CB A:CYS962 3.3 129.6 1.0 CB A:CYS907 3.4 127.8 1.0 H A:CYS964 3.4 132.8 1.0 HB3 A:CYS964 3.4 132.8 1.0 HE2 A:MET912 3.5 126.0 1.0 HB2 A:CYS962 3.5 129.6 1.0 HB2 A:CYS907 3.6 127.8 1.0 CB A:CYS964 3.6 132.8 1.0 N A:CYS910 3.6 130.3 1.0 HB3 A:GLN966 3.7 127.5 1.0 CA A:CYS910 3.9 130.3 1.0 O A:CYS910 3.9 130.3 1.0 HB3 A:ASN909 3.9 127.3 1.0 HE1 A:TRP968 4.1 121.4 1.0 N A:CYS964 4.1 132.8 1.0 HB2 A:CYS910 4.1 130.3 1.0 CE A:MET912 4.2 126.0 1.0 HE1 A:MET912 4.3 126.0 1.0 H A:LYS963 4.3 133.9 1.0 HB2 A:CYS964 4.3 132.8 1.0 C A:CYS910 4.3 130.3 1.0 HZ2 A:TRP968 4.4 121.4 1.0 HB2 A:GLN966 4.4 127.5 1.0 CA A:CYS964 4.4 132.8 1.0 H A:GLN966 4.5 127.5 1.0 CB A:GLN966 4.5 127.5 1.0 H A:ASN909 4.6 127.3 1.0 SD A:MET912 4.7 126.0 1.0 N A:LYS963 4.7 133.9 1.0 CA A:CYS962 4.7 129.6 1.0 C A:ASN909 4.7 127.3 1.0 NE1 A:TRP968 4.7 121.4 1.0 CA A:CYS907 4.8 127.8 1.0 HG2 A:MET912 4.8 126.0 1.0 HA A:CYS910 4.8 130.3 1.0 CB A:ASN909 4.8 127.3 1.0 HG2 A:GLN966 4.9 127.5 1.0 N A:ASN909 4.9 127.3 1.0 H A:LYS908 5.0 126.6 1.0

R.Singh, A.Herrero Del Valle, J.D.Joiner, M.Zwaagstra, B.J.Ferguson, F.J.M.Van Kuppeveld, Y.Modis. Molecular Basis of Autoimmune Disease Protection By MDA5 Variants Biorxiv 2024.
ISSN: ISSN 2692-8205
DOI: 10.1101/2024.10.03.616466