Zinc in PDB 9f0j: Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide

All present enzymatic activity of Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide:
3.6.4.13;

The binding sites of Zinc atom in the Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide (pdb code 9f0j). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide, PDB code: 9f0j:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the I923V MDA5-Dsrna Filament Without Nucleotide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:138.1 occ:1.00 SG A:CYS964 2.3 118.7 1.0 SG A:CYS910 2.3 111.2 1.0 SG A:CYS907 2.3 95.9 1.0 SG A:CYS962 2.3 115.1 1.0 HB3 A:CYS907 3.1 92.8 1.0 HB3 A:CYS964 3.1 108.3 1.0 HB3 A:CYS962 3.2 110.3 1.0 CB A:CYS907 3.2 93.3 1.0 CB A:CYS962 3.2 109.8 1.0 H A:CYS910 3.2 103.5 1.0 HB2 A:CYS907 3.3 92.1 1.0 H A:CYS964 3.3 107.6 1.0 HB3 A:GLN966 3.3 102.1 1.0 HB2 A:CYS962 3.3 109.0 1.0 CB A:CYS964 3.4 108.2 1.0 HE1 A:TRP968 3.7 98.5 1.0 HB2 A:GLN966 3.8 102.8 1.0 CB A:CYS910 3.8 105.2 1.0 HB3 A:CYS910 3.9 105.8 1.0 H A:GLN966 4.0 107.7 1.0 CB A:GLN966 4.0 99.2 1.0 HB2 A:ASN909 4.0 98.6 1.0 N A:CYS910 4.0 105.4 1.0 N A:CYS964 4.1 104.8 1.0 HB2 A:CYS964 4.1 110.5 1.0 HG2 A:MET912 4.2 101.5 1.0 CA A:CYS964 4.3 105.4 1.0 HZ2 A:TRP968 4.3 98.5 1.0 O A:CYS910 4.4 107.2 1.0 CA A:CYS910 4.5 104.6 1.0 H A:LYS963 4.5 107.4 1.0 NE1 A:TRP968 4.5 97.0 1.0 HB2 A:CYS910 4.5 105.4 1.0 SD A:MET912 4.5 111.1 1.0 HG2 A:GLN966 4.6 98.0 1.0 CA A:CYS907 4.6 93.3 1.0 HB3 A:ASN909 4.6 101.6 1.0 H A:ASN909 4.7 98.0 1.0 CA A:CYS962 4.7 105.2 1.0 CB A:ASN909 4.7 98.8 1.0 N A:GLN966 4.8 107.9 1.0 N A:LYS963 4.8 107.9 1.0 C A:CYS964 4.9 108.9 1.0 CG A:MET912 4.9 102.1 1.0 CG A:GLN966 4.9 95.3 1.0 C A:CYS910 5.0 103.3 1.0 HA A:CYS907 5.0 94.1 1.0 CZ2 A:TRP968 5.0 97.1 1.0 HA A:CYS962 5.0 104.3 1.0

R.Singh, A.Herrero Del Valle, J.D.Joiner, M.Zwaagstra, B.J.Ferguson, F.J.M.Van Kuppeveld, Y.Modis. Molecular Basis of Autoimmune Disease Protection By MDA5 Variants Biorxiv 2024.
ISSN: ISSN 2692-8205
DOI: 10.1101/2024.10.03.616466