Zinc in PDB 9asn: Human Drosha and DGCR8 in Complex with Pri-Mir-98

All present enzymatic activity of Human Drosha and DGCR8 in Complex with Pri-Mir-98:
3.1.26.3;

The structure of Human Drosha and DGCR8 in Complex with Pri-Mir-98 also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Zinc atom in the Human Drosha and DGCR8 in Complex with Pri-Mir-98 (pdb code 9asn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Drosha and DGCR8 in Complex with Pri-Mir-98, PDB code: 9asn:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Mir-98


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Drosha and DGCR8 in Complex with Pri-Mir-98 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1401 b:30.0 occ:1.00 NE2 A:HIS609 2.0 143.5 1.0 NE2 A:HIS680 2.0 144.0 1.0 SG A:CYS561 2.3 172.1 1.0 SG A:CYS676 2.3 178.4 1.0 CE1 A:HIS680 2.7 144.0 1.0 CE1 A:HIS609 2.7 143.5 1.0 CD2 A:HIS680 3.2 144.0 1.0 CD2 A:HIS609 3.3 143.5 1.0 CB A:CYS676 3.6 178.4 1.0 CB A:CYS561 3.6 172.1 1.0 ND1 A:HIS680 3.8 144.0 1.0 ND1 A:HIS609 3.9 143.5 1.0 CG A:HIS680 4.1 144.0 1.0 CG A:HIS609 4.2 143.5 1.0 N A:CYS561 4.6 172.1 1.0 O A:PRO677 4.6 155.2 1.0 CD2 A:LEU571 4.7 155.3 1.0 CA A:CYS561 4.7 172.1 1.0 CG1 A:VAL642 4.9 154.0 1.0 CA A:CYS676 4.9 178.4 1.0

Zinc binding site 2 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Mir-98


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Drosha and DGCR8 in Complex with Pri-Mir-98 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1402 b:30.0 occ:1.00 NE2 A:HIS1026 2.0 141.4 1.0 NE2 A:HIS549 2.0 144.1 1.0 SG A:CYS536 2.3 181.7 1.0 SG A:CYS538 2.3 190.4 1.0 CE1 A:HIS1026 2.7 141.4 1.0 CE1 A:HIS549 2.9 144.1 1.0 CD2 A:HIS549 3.1 144.1 1.0 CD2 A:HIS1026 3.2 141.4 1.0 CB A:CYS538 3.3 190.4 1.0 ND1 A:HIS1026 3.9 141.4 1.0 CB A:CYS536 3.9 181.7 1.0 ND1 A:HIS549 4.1 144.1 1.0 CG A:HIS1026 4.1 141.4 1.0 CG A:HIS549 4.2 144.1 1.0 CA A:CYS536 4.5 181.7 1.0 CA A:CYS538 4.5 190.4 1.0 N A:CYS538 4.6 190.4 1.0 N A:LYS537 4.7 180.8 1.0 CG A:ARG543 4.8 174.1 1.0 C A:CYS536 4.9 181.7 1.0 C A:LYS537 4.9 180.8 1.0 NH1 A:ARG548 5.0 148.8 1.0

A.Garg, L.Joshua-Tor. RNAI_PROTEIN_98 To Be Published.