Zinc in PDB 8y6k: Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State

All present enzymatic activity of Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State:
1.14.13.225; 1.6.3.1;

The binding sites of Zinc atom in the Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State (pdb code 8y6k). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State, PDB code: 8y6k:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn4301 b:177.8 occ:1.00 N A:HIS2852 2.1 161.6 1.0 SG A:CYS2831 2.3 155.2 1.0 SG A:CYS2855 2.3 173.4 1.0 CB A:PHE2851 2.6 159.9 1.0 CA A:PHE2851 2.8 159.9 1.0 C A:PHE2851 2.9 159.9 1.0 CG A:PHE2851 3.1 159.9 1.0 CD1 A:PHE2851 3.2 159.9 1.0 CA A:HIS2852 3.2 161.6 1.0 CB A:HIS2852 3.4 161.6 1.0 CB A:CYS2831 3.6 155.2 1.0 ND1 A:HIS2852 3.6 161.6 1.0 CB A:CYS2855 3.8 173.4 1.0 O A:HIS2852 3.8 161.6 1.0 CG A:HIS2852 3.9 161.6 1.0 C A:HIS2852 4.0 161.6 1.0 CB A:LEU2833 4.0 153.9 1.0 N A:CYS2834 4.0 157.0 1.0 O A:PHE2851 4.1 159.9 1.0 CD2 A:PHE2851 4.2 159.9 1.0 CB A:CYS2834 4.3 157.0 1.0 N A:PHE2851 4.3 159.9 1.0 CE1 A:PHE2851 4.3 159.9 1.0 C A:LEU2833 4.5 153.9 1.0 N A:LEU2833 4.5 153.9 1.0 CA A:LEU2833 4.5 153.9 1.0 CA A:CYS2831 4.7 155.2 1.0 CE1 A:HIS2852 4.8 161.6 1.0 CA A:CYS2834 4.8 157.0 1.0 O A:PHE2850 4.9 149.8 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Full-Length MICAL1 in the Autoinhibited State within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn4302 b:206.9 occ:1.00 CG A:HIS2884 1.7 194.7 1.0 CD2 A:HIS2884 2.2 194.7 1.0 ND1 A:HIS2884 2.3 194.7 1.0 SG A:CYS2861 2.3 184.8 1.0 CB A:HIS2884 2.3 194.7 1.0 SG A:CYS2858 2.3 172.1 1.0 SG A:CYS2881 2.4 177.4 1.0 NE2 A:HIS2884 2.8 194.7 1.0 OG1 A:THR2860 2.8 166.9 1.0 CE1 A:HIS2884 2.8 194.7 1.0 CB A:CYS2858 3.2 172.1 1.0 CA A:HIS2884 3.8 194.7 1.0 CB A:CYS2861 3.9 184.8 1.0 N A:CYS2861 4.1 184.8 1.0 CB A:CYS2881 4.1 177.4 1.0 CB A:THR2860 4.3 166.9 1.0 N A:HIS2884 4.4 194.7 1.0 N A:CYS2881 4.4 177.4 1.0 CA A:CYS2861 4.6 184.8 1.0 CA A:CYS2858 4.6 172.1 1.0 CA A:CYS2881 4.7 177.4 1.0 C A:HIS2884 4.8 194.7 1.0 O A:CYS2881 4.8 177.4 1.0 CG2 A:THR2860 4.8 166.9 1.0 C A:CYS2881 4.9 177.4 1.0 O A:HIS2884 4.9 194.7 1.0 N A:THR2860 5.0 166.9 1.0

L.Lin, J.Dong, S.Xu, J.Xiao, C.Yu, F.Niu, Z.Wei. Autoinhibition and Relief Mechanisms For Mical Monooxygenases in F-Actin Disassembly. Nat Commun V. 15 6824 2024.
ISSN: ESSN 2041-1723
PubMed: 39122694
DOI: 10.1038/S41467-024-50940-7