Zinc in PDB 8xzc: Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant

All present enzymatic activity of Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant:
3.4.13.4;

The structure of Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant, PDB code: 8xzc was solved by K.Chandravanshi, A.Kumar, R.D.Makde, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.82 / 2.35
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	79.935, 115.526, 124.434, 90, 90, 90
R / Rfree (%)	19.6 / 24

The binding sites of Zinc atom in the Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant (pdb code 8xzc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant, PDB code: 8xzc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn503 b:41.6 occ:0.44 OE2 A:GLU165 2.0 53.4 1.0 SG A:CYS124 2.3 64.8 1.0 NE2 A:HIS377 2.3 75.5 1.0 O A:HOH626 2.3 43.6 1.0 ZN A:ZN504 2.4 37.6 0.6 CD A:GLU165 2.8 64.3 1.0 CE1 A:HIS377 3.0 72.9 1.0 OE1 A:GLU165 3.1 67.1 1.0 CB A:CYS124 3.1 47.8 1.0 CD2 A:HIS377 3.5 72.7 1.0 NE2 A:HIS126 3.6 44.8 1.0 OE1 A:GLU164 3.8 47.5 1.0 CB A:SER349 4.2 81.5 1.0 ND1 A:HIS377 4.2 75.2 1.0 CG A:GLU165 4.2 58.6 1.0 CE1 A:HIS126 4.3 53.1 1.0 NE2 A:HIS189 4.3 57.3 1.0 O A:HOH617 4.3 47.4 1.0 CD2 A:HIS126 4.4 41.7 1.0 CG A:HIS377 4.5 76.6 1.0 CA A:CYS124 4.6 55.0 1.0 O A:HOH627 4.7 51.9 1.0 CE1 A:HIS189 4.7 51.6 1.0 CD A:GLU164 4.8 53.7 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn504 b:37.6 occ:0.60 O A:HOH626 2.0 43.6 1.0 O A:HOH617 2.2 47.4 1.0 NE2 A:HIS189 2.3 57.3 1.0 NE2 A:HIS126 2.3 44.8 1.0 SG A:CYS124 2.4 64.8 1.0 ZN A:ZN503 2.4 41.6 0.4 CE1 A:HIS189 3.1 51.6 1.0 CD2 A:HIS126 3.2 41.7 1.0 CE1 A:HIS126 3.3 53.1 1.0 CD2 A:HIS189 3.4 50.5 1.0 OE1 A:GLU164 3.4 47.5 1.0 OE2 A:GLU165 3.5 53.4 1.0 CB A:CYS124 3.8 47.8 1.0 CD A:GLU164 4.1 53.7 1.0 ND1 A:HIS189 4.3 60.0 1.0 OE1 A:GLU113 4.3 48.6 1.0 CG A:HIS126 4.4 45.0 1.0 CD A:GLU165 4.4 64.3 1.0 ND1 A:HIS126 4.4 50.1 1.0 CG A:HIS189 4.4 60.5 1.0 OE2 A:GLU164 4.4 43.1 1.0 NE2 A:HIS377 4.5 75.5 1.0 O A:CYS124 4.6 46.5 1.0 CD1 A:ILE129 4.7 42.1 1.0 CB A:SER349 4.8 81.5 1.0 OE1 A:GLU165 4.9 67.1 1.0

K.Chandravanshi, A.Kumar, R.D.Makde. Crystal Structure of Human Cytosolic Beta-Alanyl Lysine Dipeptidase (PM20D2) TYR314PHE Mutant To Be Published.