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Zinc in PDB 7bkp: Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp

Enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp

All present enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp:
3.6.4.13;

Other elements in 7bkp:

The structure of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp (pdb code 7bkp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp, PDB code: 7bkp:

Zinc binding site 1 out of 1 in 7bkp

Go back to Zinc Binding Sites List in 7bkp
Zinc binding site 1 out of 1 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1101

b:76.5
occ:1.00
SG A:CYS910 2.3 44.2 1.0
SG A:CYS964 2.3 45.6 1.0
SG A:CYS962 2.4 44.4 1.0
SG A:CYS907 2.4 41.6 1.0
HB3 A:CYS962 2.7 44.4 1.0
CB A:CYS962 2.9 44.4 1.0
HB2 A:CYS962 2.9 44.4 1.0
HB2 A:CYS907 3.0 41.6 1.0
HZ2 A:TRP968 3.1 38.1 1.0
CB A:CYS907 3.2 41.6 1.0
HE1 A:TRP968 3.3 38.1 1.0
HB3 A:CYS907 3.3 41.6 1.0
HE2 A:MET912 3.6 46.9 1.0
HB3 A:GLN966 3.6 39.2 1.0
H A:CYS964 3.8 45.6 1.0
CZ2 A:TRP968 3.8 38.1 1.0
H A:CYS910 3.8 44.2 1.0
NE1 A:TRP968 3.9 38.1 1.0
CB A:CYS964 4.0 45.6 1.0
CB A:CYS910 4.1 44.2 1.0
CE2 A:TRP968 4.2 38.1 1.0
HB3 A:CYS964 4.2 45.6 1.0
CA A:CYS962 4.4 44.4 1.0
O A:CYS910 4.4 44.2 1.0
H A:GLN966 4.4 39.2 1.0
HB3 A:CYS910 4.5 44.2 1.0
CE A:MET912 4.5 46.9 1.0
H A:LYS963 4.5 47.0 1.0
HB2 A:CYS910 4.5 44.2 1.0
N A:CYS964 4.5 45.6 1.0
CB A:GLN966 4.6 39.2 1.0
HB2 A:CYS964 4.6 45.6 1.0
N A:CYS910 4.6 44.2 1.0
CA A:CYS907 4.6 41.6 1.0
HG2 A:MET912 4.7 46.9 1.0
HB2 A:GLN966 4.7 39.2 1.0
CA A:CYS910 4.8 44.2 1.0
HA A:CYS962 4.8 44.4 1.0
HA A:CYS907 4.8 41.6 1.0
HE1 A:MET912 4.8 46.9 1.0
HB3 A:ASN909 4.8 40.1 1.0
N A:LYS963 4.9 47.0 1.0
CA A:CYS964 4.9 45.6 1.0
CH2 A:TRP968 4.9 38.1 1.0
H A:CYS962 4.9 44.4 1.0
C A:CYS962 4.9 44.4 1.0
C A:CYS910 4.9 44.2 1.0

Reference:

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5
Page generated: Thu Aug 21 22:50:01 2025

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