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Zinc in PDB 7b5s: Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1

Enzymatic activity of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1

All present enzymatic activity of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1:
2.3.2.27; 2.3.2.31; 2.3.2.32;

Zinc Binding Sites:

The binding sites of Zinc atom in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 (pdb code 7b5s). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1, PDB code: 7b5s:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 7b5s

Go back to Zinc Binding Sites List in 7b5s
Zinc binding site 1 out of 5 in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn601

b:206.8
occ:1.00
 SG H:CYS297 2.3 131.4 1.0
SG H:CYS281 2.3 135.4 1.0
SG H:CYS299 2.3 133.4 1.0
SG H:CYS276 2.3 117.2 1.0
CB H:CYS297 3.0 131.4 1.0
CB H:CYS281 3.1 135.4 1.0
CB H:CYS276 3.2 117.2 1.0
CB H:CYS299 3.3 133.4 1.0
CB H:ALA278 4.2 122.2 1.0
ND1 H:HIS283 4.3 129.1 1.0
O H:CYS297 4.3 131.4 1.0
CA H:CYS297 4.4 131.4 1.0
CA H:CYS281 4.5 135.4 1.0
CA H:CYS299 4.6 133.4 1.0
C H:CYS297 4.6 131.4 1.0
N H:CYS299 4.6 133.4 1.0
CA H:CYS276 4.7 117.2 1.0
CB H:HIS283 4.7 129.1 1.0
CG H:HIS283 4.8 129.1 1.0

Zinc binding site 2 out of 5 in 7b5s

Go back to Zinc Binding Sites List in 7b5s
Zinc binding site 2 out of 5 in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn602

b:131.7
occ:1.00
 NE2 H:HIS312 2.1 67.9 1.0
SG H:CYS307 2.3 95.3 1.0
SG H:CYS304 2.3 100.3 1.0
SG H:CYS317 2.3 71.0 1.0
CE1 H:HIS312 3.0 67.9 1.0
CD2 H:HIS312 3.1 67.9 1.0
CB H:CYS307 3.5 95.3 1.0
CB H:CYS317 3.7 71.0 1.0
CB H:CYS304 3.9 100.3 1.0
ND1 H:HIS312 4.1 67.9 1.0
CG H:HIS312 4.2 67.9 1.0
N H:CYS307 4.2 95.3 1.0
CA H:CYS317 4.4 71.0 1.0
CA H:CYS307 4.4 95.3 1.0
N H:GLY308 4.6 93.6 1.0
O H:GLU309 4.9 88.2 1.0
OE1 H:GLU309 4.9 88.2 1.0
O H:ASN310 4.9 81.4 1.0
N H:GLU309 5.0 88.2 1.0

Zinc binding site 3 out of 5 in 7b5s

Go back to Zinc Binding Sites List in 7b5s
Zinc binding site 3 out of 5 in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn201

b:65.2
occ:1.00
 ND1 R:HIS80 2.0 51.1 1.0
SG R:CYS42 2.3 46.9 1.0
SG R:CYS45 2.3 43.8 1.0
SG R:CYS83 2.3 53.1 1.0
CG R:HIS80 2.8 51.1 1.0
CE1 R:HIS80 2.9 51.1 1.0
CB R:HIS80 3.3 51.1 1.0
CB R:CYS42 3.4 46.9 1.0
CB R:CYS83 3.7 53.1 1.0
CB R:CYS45 3.8 43.8 1.0
NE2 R:HIS80 3.8 51.1 1.0
CD2 R:HIS80 3.8 51.1 1.0
N R:CYS45 4.1 43.8 1.0
N R:HIS80 4.2 51.1 1.0
CB R:CYS53 4.2 58.5 1.0
CA R:HIS80 4.4 51.1 1.0
CA R:CYS45 4.5 43.8 1.0
CA R:CYS53 4.6 58.5 1.0
CB R:ILE44 4.7 42.9 1.0
CA R:CYS42 4.8 46.9 1.0
O R:CYS42 4.9 46.9 1.0

Zinc binding site 4 out of 5 in 7b5s

Go back to Zinc Binding Sites List in 7b5s
Zinc binding site 4 out of 5 in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn202

b:105.7
occ:1.00
 OD2 R:ASP97 2.0 81.0 1.0
ND1 R:HIS77 2.0 67.0 1.0
SG R:CYS75 2.3 75.1 1.0
SG R:CYS94 2.3 70.7 1.0
CG R:ASP97 2.7 81.0 1.0
OD1 R:ASP97 2.8 81.0 1.0
CE1 R:HIS77 2.8 67.0 1.0
CG R:HIS77 3.2 67.0 1.0
CB R:CYS94 3.5 70.7 1.0
CB R:CYS75 3.6 75.1 1.0
CB R:HIS77 3.7 67.0 1.0
NE2 R:HIS77 4.0 67.0 1.0
CB R:ASP97 4.1 81.0 1.0
CD2 R:HIS77 4.2 67.0 1.0
CZ3 R:TRP101 4.5 69.7 1.0
CE3 R:TRP101 4.5 69.7 1.0
CA R:CYS94 4.8 70.7 1.0
CA R:CYS75 4.8 75.1 1.0
O R:CYS75 4.8 75.1 1.0
C R:CYS75 4.9 75.1 1.0
CA R:HIS77 4.9 67.0 1.0
N R:HIS77 5.0 67.0 1.0
N R:ASP97 5.0 81.0 1.0

Zinc binding site 5 out of 5 in 7b5s

Go back to Zinc Binding Sites List in 7b5s
Zinc binding site 5 out of 5 in the Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Ubiquitin Ligation to F-Box Protein Substrates By Scf-Rbr E3-E3 Super- Assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
R:Zn203

b:102.7
occ:1.00
 ND1 R:HIS82 2.0 57.2 1.0
SG R:CYS53 2.3 58.5 1.0
SG R:CYS68 2.3 65.6 1.0
SG R:CYS56 2.3 61.7 1.0
CE1 R:HIS82 2.7 57.2 1.0
CB R:CYS68 3.0 65.6 1.0
CG R:HIS82 3.2 57.2 1.0
CB R:CYS56 3.3 61.7 1.0
CB R:CYS53 3.4 58.5 1.0
CB R:HIS82 3.8 57.2 1.0
N R:CYS56 3.9 61.7 1.0
NE2 R:HIS82 4.0 57.2 1.0
CA R:CYS68 4.0 65.6 1.0
N R:CYS53 4.1 58.5 1.0
CA R:CYS56 4.2 61.7 1.0
CD2 R:HIS82 4.2 57.2 1.0
CA R:CYS53 4.3 58.5 1.0
CB R:GLU55 4.9 58.7 1.0
N R:CYS68 5.0 65.6 1.0
N R:HIS82 5.0 57.2 1.0
C R:CYS53 5.0 58.5 1.0
C R:GLU55 5.0 58.7 1.0

Reference:

D.Horn-Ghetko, D.T.Krist, J.R.Prabu, B.Kheewong, M.M.P.C.Mulder, D.C.Scott, M.Klugel, H.Ovaa, G.Kleiger, B.Schulman. Ubiquitin Ligation to F-Box Protein Targets By Scf-Rbr E3-E3 Super-Assembly Nature 2021.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-021-03197-9
Page generated: Tue Oct 29 17:27:14 2024

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