Zinc in PDB 6tpm: Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655)

All present enzymatic activity of Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655):
3.5.2.6;

The structure of Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655), PDB code: 6tpm was solved by P.A.Lang, T.M.Leissing, C.J.Schofield, J.Brem, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.17 / 1.72
Space group	P 43 3 2
Cell size a, b, c (Å), α, β, γ (°)	138.500, 138.500, 138.500, 90.00, 90.00, 90.00
R / Rfree (%)	16.9 / 19.5

The structure of Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655) also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655) (pdb code 6tpm). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655), PDB code: 6tpm:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn603 b:24.6 occ:0.33 NE2 A:HIS13 2.1 29.5 1.0 CL A:CL608 2.2 26.4 0.3 CD2 A:HIS13 3.0 25.5 1.0 CE1 A:HIS13 3.1 26.9 1.0 ND1 A:HIS13 4.2 24.3 1.0 CG A:HIS13 4.2 23.5 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Ampc From E.Coli with Relebactam (Mk-7655) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:34.8 occ:0.41 O A:HOH797 1.8 46.0 1.0 O A:HOH853 1.9 42.0 1.0 O A:HOH772 2.0 44.6 1.0 O A:HOH936 2.1 34.0 0.5 NE2 A:HIS186 2.2 51.8 1.0 CE1 A:HIS186 3.1 55.8 1.0 CD2 A:HIS186 3.2 48.7 1.0 O A:HOH799 3.9 58.7 1.0 O A:HOH947 4.0 54.2 1.0 ND1 A:HIS186 4.2 45.8 1.0 OE2 A:GLU195 4.2 59.1 1.0 CG A:HIS186 4.3 40.3 1.0 OE1 A:GLU195 4.3 54.3 1.0 CD A:GLU195 4.7 61.3 1.0

P.A.Lang, T.M.Leissing, M.G.P.Page, C.J.Schofield, J.Brem. Structural Investigations of the Inhibition of Escherichia Coli Ampc Beta-Lactamase By Diazabicyclooctanes. Antimicrob.Agents Chemother. 2020.
ISSN: ESSN 1098-6596
PubMed: 33199391
DOI: 10.1128/AAC.02073-20