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Zinc in PDB 5y3e: Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol

Enzymatic activity of Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol

All present enzymatic activity of Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol:
3.4.19.12; 3.4.22.69;

Protein crystallography data

The structure of Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol, PDB code: 5y3e was solved by M.H.Lin, C.Y.Chou, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.47 / 1.65
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 151.179, 33.357, 90.890, 90.00, 124.98, 90.00
R / Rfree (%) 16.2 / 19.9

Other elements in 5y3e:

The structure of Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol also contains other interesting chemical elements:

Sodium (Na) 5 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol (pdb code 5y3e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol, PDB code: 5y3e:

Zinc binding site 1 out of 1 in 5y3e

Go back to Zinc Binding Sites List in 5y3e
Zinc binding site 1 out of 1 in the Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Sars Coronavirus Papain-Like Protease in Complex with Glycerol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:33.1
occ:1.00
 SG A:CYS193 2.2 42.9 1.0
SG A:CYS225 2.3 32.7 1.0
SG A:CYS227 2.3 31.7 1.0
SG A:CYS190 2.4 30.6 1.0
CB A:CYS193 3.2 39.7 1.0
CB A:CYS225 3.3 33.4 1.0
CB A:CYS227 3.3 33.0 1.0
CB A:CYS190 3.4 29.4 1.0
N A:CYS193 3.8 36.2 1.0
N A:CYS227 4.1 36.5 1.0
CA A:CYS193 4.2 37.4 1.0
CA A:CYS227 4.3 33.1 1.0
CB A:HIS192 4.5 41.1 1.0
CA A:CYS225 4.6 32.8 1.0
O A:HOH709 4.6 31.3 1.0
CB A:ARG229 4.7 36.3 1.0
CA A:CYS190 4.8 29.7 1.0
C A:CYS225 4.8 32.9 1.0
C A:HIS192 4.8 38.0 1.0
N A:VAL226 4.9 36.2 1.0
CD A:ARG229 5.0 38.4 1.0

Reference:

M.H.Lin, D.C.Moses, C.H.Hsieh, S.C.Cheng, Y.H.Chen, C.Y.Sun, C.Y.Chou. Disulfiram Can Inhibit Mers and Sars Coronavirus Papain-Like Proteases Via Different Modes Antiviral Res. V. 150 155 2017.
ISSN: ISSN 1872-9096
PubMed: 29289665
DOI: 10.1016/J.ANTIVIRAL.2017.12.015
Page generated: Mon Oct 28 15:25:59 2024

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