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Zinc in PDB 5b8i: Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs

Enzymatic activity of Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs

All present enzymatic activity of Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs:
3.1.3.16;

Protein crystallography data

The structure of Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs, PDB code: 5b8i was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), D.Fox Iii, D.M.Dranow, D.D.Lorimer, T.E.Edwards, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.27 / 1.85
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 94.670, 154.630, 64.750, 90.00, 90.00, 90.00
R / Rfree (%) 14.5 / 17.2

Other elements in 5b8i:

The structure of Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs also contains other interesting chemical elements:

Iron (Fe) 1 atom
Calcium (Ca) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs (pdb code 5b8i). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs, PDB code: 5b8i:

Zinc binding site 1 out of 1 in 5b8i

Go back to Zinc Binding Sites List in 5b8i
Zinc binding site 1 out of 1 in the Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:19.6
occ:0.67
 O A:HOH851 1.8 26.5 1.0
OD1 A:ASN168 2.1 13.8 1.0
NE2 A:HIS217 2.3 11.9 1.0
OD2 A:ASP136 2.3 11.7 1.0
ND1 A:HIS299 2.3 13.1 1.0
O3S A:MES403 2.5 23.3 0.7
CG A:ASN168 3.1 15.9 1.0
CE1 A:HIS299 3.2 15.0 1.0
FE A:FE402 3.2 15.2 0.5
CE1 A:HIS217 3.2 11.2 1.0
CG A:ASP136 3.2 15.9 1.0
CD2 A:HIS217 3.3 9.8 1.0
CG A:HIS299 3.4 16.1 1.0
S A:MES403 3.5 25.8 0.7
ND2 A:ASN168 3.5 12.8 1.0
O1S A:MES403 3.5 24.3 0.7
OD1 A:ASP136 3.6 13.2 1.0
CA A:HIS299 3.7 13.9 1.0
CB A:HIS299 3.8 13.6 1.0
OD2 A:ASP108 4.0 21.0 1.0
O A:HIS299 4.1 15.6 1.0
C8 A:MES403 4.3 21.9 0.7
CD2 A:HIS169 4.3 12.7 1.0
C7 A:MES403 4.3 20.6 0.7
ND1 A:HIS217 4.3 10.9 1.0
NE2 A:HIS299 4.4 14.4 1.0
CB A:ASN168 4.4 12.0 1.0
CG A:HIS217 4.4 9.4 1.0
C A:HIS299 4.4 13.7 1.0
CD2 A:HIS299 4.5 13.3 1.0
N A:ASN168 4.5 11.5 1.0
CB A:ASP136 4.5 11.0 1.0
O A:HOH852 4.6 24.9 1.0
O A:LEU249 4.7 14.8 1.0
N A:HIS299 4.8 13.0 1.0
O2S A:MES403 4.8 21.9 0.7
CG A:ASP108 4.9 15.0 1.0
NE2 A:HIS169 4.9 15.6 1.0
OD1 A:ASP108 4.9 14.4 1.0
CA A:ASN168 5.0 10.6 1.0
NE2 A:HIS110 5.0 12.6 1.0

Reference:

Seattle Structural Genomics Center For Infectious Disease(Ssgcid), D.Fox Iii, D.M.Dranow, D.D.Lorimer, T.E.Edwards. Crystal Structure of Calcineurin A and Calcineurin B in Complex with FKBP12 and FK506 From Coccidioides Immitis Rs To Be Published.
Page generated: Sun Oct 27 13:27:29 2024

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