Atomistry » Zinc » PDB 4y93-4ymk » 4y94
Atomistry »
  Zinc »
    PDB 4y93-4ymk »
      4y94 »

Zinc in PDB 4y94: Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate

Enzymatic activity of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate

All present enzymatic activity of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate:
2.7.10.2;

Protein crystallography data

The structure of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate, PDB code: 4y94 was solved by Q.Wang, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.48 / 2.40
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 37.203, 64.012, 80.029, 82.08, 88.79, 89.89
R / Rfree (%) 22.9 / 25.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate (pdb code 4y94). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate, PDB code: 4y94:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 4y94

Go back to Zinc Binding Sites List in 4y94
Zinc binding site 1 out of 4 in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn202

b:54.9
occ:1.00
 ND1 B:HIS143 2.1 55.9 1.0
SG B:CYS154 2.4 55.0 1.0
SG B:CYS165 2.4 52.8 1.0
SG B:CYS155 2.5 59.9 1.0
CE1 B:HIS143 3.0 54.8 1.0
CG B:HIS143 3.2 53.8 1.0
CB B:CYS165 3.2 68.9 1.0
CB B:CYS155 3.3 54.7 1.0
CB B:CYS154 3.5 65.4 1.0
CB B:HIS143 3.6 44.2 1.0
N B:CYS155 3.8 60.3 1.0
C B:CYS154 3.9 62.3 1.0
CA B:HIS143 4.0 55.6 1.0
N B:CYS165 4.0 64.7 1.0
CB B:TYR152 4.2 64.2 1.0
CA B:CYS155 4.2 55.3 1.0
NE2 B:HIS143 4.2 60.5 1.0
CA B:CYS154 4.2 55.6 1.0
CA B:CYS165 4.3 60.9 1.0
CD2 B:HIS143 4.3 56.7 1.0
CD B:PRO144 4.5 58.9 1.0
O B:CYS154 4.5 60.5 1.0
CG B:TYR152 4.5 60.7 1.0
N B:CYS154 4.7 56.4 1.0
O B:TYR142 4.9 50.7 1.0
CD2 B:TYR152 4.9 54.0 1.0
NE2 B:GLN157 4.9 68.3 1.0
C B:GLY164 4.9 54.6 1.0
C B:HIS143 5.0 53.7 1.0
N B:HIS143 5.0 60.8 1.0

Zinc binding site 2 out of 4 in 4y94

Go back to Zinc Binding Sites List in 4y94
Zinc binding site 2 out of 4 in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn202

b:49.1
occ:1.00
 SG C:CYS165 2.3 47.0 1.0
SG C:CYS155 2.3 59.2 1.0
ND1 C:HIS143 2.3 53.2 1.0
SG C:CYS154 2.4 54.9 1.0
CB C:CYS165 3.2 63.7 1.0
CB C:CYS155 3.2 60.9 1.0
CE1 C:HIS143 3.2 54.6 1.0
CG C:HIS143 3.4 52.0 1.0
CB C:CYS154 3.5 49.1 1.0
N C:CYS155 3.7 56.1 1.0
CB C:HIS143 3.8 35.8 1.0
C C:CYS154 3.9 56.0 1.0
N C:CYS165 3.9 58.7 1.0
CA C:HIS143 4.0 40.8 1.0
CA C:CYS155 4.1 53.4 1.0
CB C:TYR152 4.1 54.4 1.0
CA C:CYS154 4.2 51.0 1.0
CA C:CYS165 4.2 54.0 1.0
NE2 C:HIS143 4.4 51.0 1.0
O C:CYS154 4.4 55.2 1.0
CD C:PRO144 4.4 44.1 1.0
CG C:TYR152 4.5 54.2 1.0
CD2 C:HIS143 4.5 46.5 1.0
N C:CYS154 4.6 44.7 1.0
O C:TYR142 4.8 50.7 1.0
C C:GLY164 4.9 56.6 1.0
NE2 C:GLN157 4.9 73.7 1.0
CD2 C:TYR152 4.9 48.9 1.0
N C:HIS143 5.0 50.4 1.0
C C:HIS143 5.0 48.0 1.0

Zinc binding site 3 out of 4 in 4y94

Go back to Zinc Binding Sites List in 4y94
Zinc binding site 3 out of 4 in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn503

b:59.9
occ:1.00
 SG A:CYS165 2.2 65.3 1.0
ND1 A:HIS143 2.3 67.1 1.0
SG A:CYS155 2.3 80.5 1.0
SG A:CYS154 2.6 59.0 1.0
CE1 A:HIS143 3.1 70.2 1.0
CB A:CYS155 3.2 70.0 1.0
CG A:HIS143 3.3 64.3 1.0
CB A:CYS154 3.6 60.8 1.0
N A:CYS155 3.7 70.5 1.0
CB A:CYS165 3.7 63.1 1.0
CB A:HIS143 3.7 60.6 1.0
C A:CYS154 3.9 65.5 1.0
CB A:TYR152 3.9 63.9 1.0
CA A:CYS155 4.0 68.2 1.0
CA A:HIS143 4.0 62.9 1.0
CA A:CYS154 4.2 65.9 1.0
N A:CYS165 4.2 68.8 1.0
NE2 A:HIS143 4.3 68.5 1.0
CG A:TYR152 4.3 66.9 1.0
CD2 A:HIS143 4.4 65.6 1.0
O A:CYS154 4.4 64.8 1.0
CA A:CYS165 4.6 73.4 1.0
N A:CYS154 4.6 60.8 1.0
CD2 A:TYR152 4.7 67.8 1.0
CD A:PRO144 4.8 62.9 1.0
O A:TYR142 4.9 66.3 1.0
CD1 A:TYR152 4.9 65.1 1.0
N A:HIS143 5.0 62.2 1.0

Zinc binding site 4 out of 4 in 4y94

Go back to Zinc Binding Sites List in 4y94
Zinc binding site 4 out of 4 in the Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of the pH-Th Module of Bruton'S Tyrosine Kinase Bound to Inositol Hexakisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn203

b:86.7
occ:1.00
 SG D:CYS155 2.5 99.6 1.0
SG D:CYS154 2.5 69.2 1.0
SG D:CYS165 2.5 81.8 1.0
ND1 D:HIS143 2.5 86.5 1.0
CB D:CYS155 3.1 88.7 1.0
CB D:CYS165 3.1 86.1 1.0
CE1 D:HIS143 3.2 83.1 1.0
CB D:CYS154 3.3 85.2 1.0
N D:CYS155 3.6 94.0 1.0
CG D:HIS143 3.7 81.9 1.0
C D:CYS154 3.7 89.5 1.0
N D:CYS165 3.9 79.7 1.0
CA D:CYS155 4.0 88.6 1.0
CA D:CYS154 4.1 85.8 1.0
CB D:HIS143 4.1 68.4 1.0
O D:CYS154 4.1 92.0 1.0
CA D:CYS165 4.1 84.1 1.0
CA D:HIS143 4.3 69.4 1.0
NE2 D:HIS143 4.4 85.2 1.0
CB D:TYR152 4.5 85.2 1.0
CD D:PRO144 4.6 66.8 1.0
N D:CYS154 4.6 84.5 1.0
CD2 D:HIS143 4.7 88.9 1.0
C D:GLY164 4.7 81.8 1.0
O D:TYR142 4.8 76.7 1.0
CG D:TYR152 4.9 85.3 1.0

Reference:

Q.Wang, E.M.Vogan, L.M.Nocka, C.E.Rosen, J.A.Zorn, S.C.Harrison, J.Kuriyan. Autoinhibition of Bruton'S Tyrosine Kinase (Btk) and Activation By Soluble Inositol Hexakisphosphate. Elife V. 4 2015.
ISSN: ESSN 2050-084X
PubMed: 25699547
DOI: 10.7554/ELIFE.06074
Page generated: Sun Oct 27 11:02:11 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy