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Atomistry » Zinc » PDB 4pa5-4ppe » 4pf9 » |
Zinc in PDB 4pf9: Crystal Structure of Insulin Degrading Enzyme Complexed with InhibitorEnzymatic activity of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
All present enzymatic activity of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor:
3.4.24.56; Protein crystallography data
The structure of Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor, PDB code: 4pf9
was solved by
Y.Wang,
S.Guo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
(pdb code 4pf9). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor, PDB code: 4pf9: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4pf9Go back to![]() ![]()
Zinc binding site 1 out
of 2 in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 4pf9Go back to![]() ![]()
Zinc binding site 2 out
of 2 in the Crystal Structure of Insulin Degrading Enzyme Complexed with Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
T.B.Durham,
J.L.Toth,
V.J.Klimkowski,
J.X.Cao,
A.M.Siesky,
J.Alexander-Chacko,
G.Y.Wu,
J.T.Dixon,
J.E.Mcgee,
Y.Wang,
S.Y.Guo,
R.N.Cavitt,
J.Schindler,
S.J.Thibodeaux,
N.A.Calvert,
M.J.Coghlan,
D.K.Sindelar,
M.Christe,
V.V.Kiselyov,
M.D.Michael,
K.W.Sloop.
Dual Exosite-Binding Inhibitors of Insulin-Degrading Enzyme Challenge Its Role As the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem. V. 290 20044 2015.
Page generated: Sun Oct 27 05:52:53 2024
ISSN: ESSN 1083-351X PubMed: 26085101 DOI: 10.1074/JBC.M115.638205 |
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