Zinc in PDB 4dnc: Crystal Structure of Human Mof in Complex with MSL1

All present enzymatic activity of Crystal Structure of Human Mof in Complex with MSL1:
2.3.1.48;

The structure of Crystal Structure of Human Mof in Complex with MSL1, PDB code: 4dnc was solved by J.Huang, M.Lei, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.99 / 2.05
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	64.801, 111.518, 66.751, 90.00, 111.05, 90.00
R / Rfree (%)	20.8 / 24.6

The binding sites of Zinc atom in the Crystal Structure of Human Mof in Complex with MSL1 (pdb code 4dnc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Human Mof in Complex with MSL1, PDB code: 4dnc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of Human Mof in Complex with MSL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Mof in Complex with MSL1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:41.4 occ:1.00 NE2 A:HIS226 2.2 41.8 1.0 SG A:CYS213 2.3 36.9 1.0 SG A:CYS230 2.4 42.7 1.0 SG A:CYS210 2.4 35.4 1.0 CE1 A:HIS226 3.1 45.5 1.0 CB A:CYS230 3.2 48.5 1.0 CB A:CYS210 3.2 32.2 1.0 CD2 A:HIS226 3.2 44.9 1.0 CB A:CYS213 3.3 43.6 1.0 N A:CYS213 3.9 33.8 1.0 CA A:CYS213 4.1 32.9 1.0 ND1 A:HIS226 4.2 47.7 1.0 O A:HOH649 4.3 37.8 1.0 CG A:HIS226 4.3 46.1 1.0 CA A:CYS230 4.6 47.0 1.0 CA A:CYS210 4.7 35.2 1.0 C A:CYS213 4.8 32.9 1.0 CD1 A:TRP232 4.9 45.6 0.7 N A:LEU214 5.0 31.1 1.0 C A:TYR212 5.0 35.0 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of Human Mof in Complex with MSL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Human Mof in Complex with MSL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:36.4 occ:1.00 NE2 B:HIS226 2.1 35.4 1.0 SG B:CYS213 2.3 34.8 1.0 SG B:CYS230 2.4 37.7 1.0 SG B:CYS210 2.5 32.5 1.0 CE1 B:HIS226 2.9 42.5 1.0 CB B:CYS210 3.2 29.6 1.0 CB B:CYS230 3.2 41.7 1.0 CD2 B:HIS226 3.2 39.8 1.0 CB B:CYS213 3.4 36.1 1.0 N B:CYS213 3.9 33.3 1.0 ND1 B:HIS226 4.1 39.7 1.0 CA B:CYS213 4.2 29.6 1.0 CG B:HIS226 4.2 44.1 1.0 O B:HOH652 4.3 39.9 1.0 O B:HOH661 4.5 35.5 1.0 CA B:CYS230 4.6 46.1 1.0 CA B:CYS210 4.6 32.8 1.0 C B:CYS213 4.8 30.2 1.0 N B:LEU214 5.0 30.8 1.0

J.Huang, B.Wan, L.Wu, Y.Yang, Y.Dou, M.Lei. Structural Insight Into the Regulation of Mof in the Male-Specific Lethal Complex and the Non-Specific Lethal Complex. Cell Res. V. 22 1078 2012.
ISSN: ISSN 1001-0602
PubMed: 22547026
DOI: 10.1038/CR.2012.72