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Zinc in PDB 4b7k: Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer):
1.14.11.16; 1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer), PDB code: 4b7k was solved by R.Chowdhury, W.Ge, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.91 / 2.39
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.355, 86.355, 148.308, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 24.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer) (pdb code 4b7k). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer), PDB code: 4b7k:

Zinc binding site 1 out of 1 in 4b7k

Go back to Zinc Binding Sites List in 4b7k
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:50.0
occ:1.00
 O2 A:OGA601 2.1 49.8 1.0
O2' A:OGA601 2.1 49.4 1.0
NE2 A:HIS279 2.2 42.4 1.0
OD2 A:ASP201 2.3 44.3 1.0
NE2 A:HIS199 2.3 45.8 1.0
C1 A:OGA601 2.8 48.5 1.0
C2 A:OGA601 2.8 49.1 1.0
OG B:SER16 2.9 76.5 0.5
CG A:ASP201 3.1 44.2 1.0
CE1 A:HIS279 3.1 41.5 1.0
OD1 A:ASP201 3.2 46.9 1.0
CD2 A:HIS279 3.2 42.3 1.0
CD2 A:HIS199 3.3 42.8 1.0
CE1 A:HIS199 3.3 44.8 1.0
O1 A:OGA601 4.0 51.0 1.0
CB B:SER16 4.1 78.5 0.5
N1 A:OGA601 4.1 47.1 1.0
CZ2 A:TRP296 4.2 46.9 1.0
O A:HOH2047 4.2 46.9 1.0
OG B:SER16 4.2 76.5 0.5
CB B:SER16 4.3 78.5 0.5
ND1 A:HIS279 4.3 44.5 1.0
CG A:HIS279 4.3 44.2 1.0
ND1 A:HIS199 4.4 44.3 1.0
CG A:HIS199 4.4 43.9 1.0
CB A:ASP201 4.5 45.4 1.0
C4 A:OGA601 4.9 48.7 1.0
CH2 A:TRP296 4.9 50.5 1.0
O A:HOH2035 5.0 71.9 1.0

Reference:

M.Yang, A.P.Hardy, R.Chowdhury, N.D.Loik, J.S.Scotti, J.S.Mccullagh, T.D.Claridge, M.A.Mcdonough, W.Ge, C.J.Schofield. Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor. Angew. Chem. Int. Ed. Engl. V. 52 1700 2013.
ISSN: ESSN 1521-3773
PubMed: 23296631
DOI: 10.1002/ANIE.201208046
Page generated: Wed Aug 20 16:06:23 2025

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