Zinc in PDB 4o67: Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp

The structure of Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp, PDB code: 4o67 was solved by X.Zhang, Z.Chen, X.W.Zhang, Z.J.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.87 / 2.44
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	47.822, 118.542, 124.025, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 28.1

The binding sites of Zinc atom in the Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp (pdb code 4o67). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp, PDB code: 4o67:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:43.9 occ:1.00 NE2 A:HIS390 2.1 40.4 1.0 SG A:CYS397 2.3 44.4 1.0 SG A:CYS404 2.3 30.7 1.0 SG A:CYS396 2.3 39.1 1.0 CD2 A:HIS390 2.9 35.4 1.0 CE1 A:HIS390 3.2 31.7 1.0 CB A:CYS397 3.4 34.5 1.0 CB A:CYS404 3.4 36.3 1.0 CB A:CYS396 3.4 35.0 1.0 O A:HOH721 3.8 42.7 1.0 N A:CYS397 3.8 41.2 1.0 C A:CYS396 3.8 42.3 1.0 N A:CYS404 4.0 31.8 1.0 CG A:HIS390 4.1 41.8 1.0 CA A:CYS396 4.2 48.0 1.0 CA A:CYS397 4.2 41.9 1.0 ND1 A:HIS390 4.2 34.8 1.0 O A:CYS396 4.2 37.7 1.0 CA A:CYS404 4.3 39.6 1.0 NH2 A:ARG406 4.4 23.8 1.0 O A:GLU402 4.5 48.8 1.0 C A:CYS404 4.7 43.9 1.0 O A:CYS404 4.7 43.1 1.0 O A:HOH743 4.9 46.2 1.0

Zinc binding site 2 out of 2 in the Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Cyclic Gmp-Amp Synthase (Cgas) in Complex with Gamp within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1102 b:44.4 occ:1.00 NE2 B:HIS390 2.0 38.2 1.0 SG B:CYS397 2.2 46.4 1.0 SG B:CYS396 2.4 45.3 1.0 SG B:CYS404 2.4 33.2 1.0 CD2 B:HIS390 3.0 31.3 1.0 CE1 B:HIS390 3.1 30.4 1.0 CB B:CYS397 3.4 28.5 1.0 CB B:CYS404 3.5 18.6 1.0 O B:HOH1205 3.5 29.0 1.0 CB B:CYS396 3.5 38.7 1.0 C B:CYS396 3.8 37.7 1.0 N B:CYS397 3.8 33.0 1.0 N B:CYS404 3.9 42.4 1.0 O B:CYS396 4.1 43.0 1.0 CG B:HIS390 4.1 34.3 1.0 ND1 B:HIS390 4.2 34.5 1.0 CA B:CYS404 4.2 30.0 1.0 CA B:CYS397 4.2 30.1 1.0 CA B:CYS396 4.2 46.7 1.0 NH2 B:ARG406 4.4 33.4 1.0 O B:CYS404 4.5 40.8 1.0 O B:GLU402 4.6 54.3 1.0 C B:CYS404 4.6 47.8 1.0 O B:HOH1203 4.8 39.9 1.0

X.Zhang, J.Wu, F.Du, H.Xu, L.Sun, Z.Chen, C.A.Brautigam, X.Zhang, Z.J.Chen. The Cytosolic Dna Sensor Cgas Forms An Oligomeric Complex with Dna and Undergoes Switch-Like Conformational Changes in the Activation Loop. Cell Rep V. 6 421 2014.
ISSN: ESSN 2211-1247
PubMed: 24462292
DOI: 10.1016/J.CELREP.2014.01.003