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Zinc in PDB 3dcs: Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties
Enzymatic activity of Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties
All present enzymatic activity of Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties, PDB code: 3dcs
was solved by
C.Genis,
K.H.Sippel,
N.Case,
L.Govindasamy,
M.Agbandje-Mckenna,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.910, 41.840, 73.000, 90.00, 104.55, 90.00 |
| R / Rfree (%) | n/a / 21.4 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties
(pdb code 3dcs). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties, PDB code: 3dcs:
In total only one binding site of Zinc was determined in the Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties, PDB code: 3dcs:
Zinc binding site 1 out of 1 in 3dcs
Go back to
Zinc Binding Sites List in 3dcs
Zinc binding site 1 out
of 1 in the Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Use of Carbonic Anhydrase II, IX Active-Site Mimic, For the Purpose of Screening Inhibitors For Possible Anti-Cancer Properties within 5.0Å range:
|
Reference:
C.Genis,
K.H.Sippel,
N.Case,
W.Cao,
B.S.Avvaru,
L.J.Tartaglia,
L.Govindasamy,
C.Tu,
M.Agbandje-Mckenna,
D.N.Silverman,
C.J.Rosser,
R.Mckenna.
Design of A Carbonic Anhydrase IX Active-Site Mimic to Screen Inhibitors For Possible Anticancer Properties Biochemistry V. 48 1322 2009.
ISSN: ISSN 0006-2960
PubMed: 19170619
DOI: 10.1021/BI802035F
Page generated: Thu Oct 24 12:09:12 2024
ISSN: ISSN 0006-2960
PubMed: 19170619
DOI: 10.1021/BI802035F
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