Zinc in PDB 2mq1: Phosphotyrosine Binding Domain

The binding sites of Zinc atom in the Phosphotyrosine Binding Domain (pdb code 2mq1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Phosphotyrosine Binding Domain, PDB code: 2mq1:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Phosphotyrosine Binding Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Phosphotyrosine Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn101 b:0.0 occ:1.00 SG A:CYS25 2.3 0.0 1.0 SG A:CYS7 2.3 0.0 1.0 SG A:CYS28 2.4 0.0 1.0 SG A:CYS4 2.5 0.0 1.0 HB2 A:CYS7 3.0 0.0 1.0 HB3 A:CYS4 3.2 0.0 1.0 CB A:CYS25 3.2 0.0 1.0 HB3 A:CYS25 3.2 0.0 1.0 CB A:CYS7 3.2 0.0 1.0 HB2 A:LEU9 3.3 0.0 1.0 CB A:CYS4 3.3 0.0 1.0 HB2 A:CYS25 3.4 0.0 1.0 HB2 A:CYS4 3.4 0.0 1.0 HB2 A:CYS28 3.5 0.0 1.0 CB A:CYS28 3.6 0.0 1.0 HB3 A:CYS7 3.6 0.0 1.0 H A:LEU9 4.1 0.0 1.0 HB3 A:CYS28 4.1 0.0 1.0 H A:CYS28 4.1 0.0 1.0 CB A:LEU9 4.2 0.0 1.0 HB3 A:LEU9 4.2 0.0 1.0 H A:CYS7 4.3 0.0 1.0 H A:CYS25 4.3 0.0 1.0 CA A:CYS7 4.5 0.0 1.0 CA A:CYS25 4.6 0.0 1.0 HD22 A:LEU9 4.6 0.0 1.0 CA A:CYS4 4.7 0.0 1.0 N A:CYS7 4.8 0.0 1.0 HG12 A:ILE11 4.8 0.0 1.0 N A:LEU9 4.8 0.0 1.0 N A:CYS28 4.8 0.0 1.0 O A:LEU9 4.8 0.0 1.0 CA A:CYS28 4.8 0.0 1.0 N A:CYS25 4.8 0.0 1.0 H A:CYS4 4.8 0.0 1.0 HB3 A:ASP27 4.9 0.0 1.0 HD3 A:LYS6 4.9 0.0 1.0 HA A:ILE11 4.9 0.0 1.0 H A:GLY8 4.9 0.0 1.0 CA A:LEU9 5.0 0.0 1.0 HD21 A:LEU9 5.0 0.0 1.0

Zinc binding site 2 out of 3 in the Phosphotyrosine Binding Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Phosphotyrosine Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn102 b:0.0 occ:1.00 ND1 A:HIS22 2.1 0.0 1.0 HB2 A:HIS22 2.2 0.0 1.0 SG A:CYS43 2.3 0.0 1.0 SG A:CYS20 2.4 0.0 1.0 SG A:CYS40 2.4 0.0 1.0 CG A:HIS22 2.6 0.0 1.0 CB A:HIS22 2.7 0.0 1.0 HB3 A:HIS22 3.0 0.0 1.0 HB3 A:CYS20 3.0 0.0 1.0 CE1 A:HIS22 3.1 0.0 1.0 HE1 A:PHE24 3.2 0.0 1.0 HB2 A:CYS43 3.2 0.0 1.0 CB A:CYS20 3.2 0.0 1.0 HZ A:PHE24 3.3 0.0 1.0 CB A:CYS43 3.3 0.0 1.0 CB A:CYS40 3.5 0.0 1.0 HB2 A:CYS20 3.6 0.0 1.0 HB2 A:CYS40 3.6 0.0 1.0 HE1 A:HIS22 3.7 0.0 1.0 CD2 A:HIS22 3.7 0.0 1.0 HB3 A:CYS40 3.7 0.0 1.0 HB3 A:CYS43 3.8 0.0 1.0 CE1 A:PHE24 3.9 0.0 1.0 H A:CYS43 4.0 0.0 1.0 NE2 A:HIS22 4.0 0.0 1.0 CZ A:PHE24 4.0 0.0 1.0 H A:HIS22 4.1 0.0 1.0 CA A:HIS22 4.1 0.0 1.0 HB2 A:ASP45 4.2 0.0 1.0 HB2 A:MET17 4.3 0.0 1.0 N A:HIS22 4.5 0.0 1.0 HD2 A:HIS22 4.5 0.0 1.0 CA A:CYS43 4.6 0.0 1.0 CA A:CYS20 4.6 0.0 1.0 N A:CYS43 4.6 0.0 1.0 HA A:HIS22 4.7 0.0 1.0 HD2 A:PRO41 4.8 0.0 1.0 HE2 A:HIS22 4.9 0.0 1.0 SD A:MET17 4.9 0.0 1.0 CA A:CYS40 4.9 0.0 1.0 C A:CYS20 4.9 0.0 1.0 HA A:CYS20 4.9 0.0 1.0 H A:ASP45 4.9 0.0 1.0 C A:HIS22 5.0 0.0 1.0

Zinc binding site 3 out of 3 in the Phosphotyrosine Binding Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Phosphotyrosine Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn103 b:0.0 occ:1.00 NE2 A:HIS80 2.0 0.0 1.0 NE2 A:HIS85 2.1 0.0 1.0 HE1 A:HIS85 2.3 0.0 1.0 SG A:CYS61 2.4 0.0 1.0 CE1 A:HIS85 2.4 0.0 1.0 SG A:CYS67 2.4 0.0 1.0 HD2 A:HIS80 2.5 0.0 1.0 CD2 A:HIS80 2.5 0.0 1.0 HB3 A:CYS67 3.0 0.0 1.0 CD2 A:HIS85 3.2 0.0 1.0 CB A:CYS67 3.3 0.0 1.0 CE1 A:HIS80 3.3 0.0 1.0 HD12 A:ILE81 3.4 0.0 1.0 ND1 A:HIS85 3.5 0.0 1.0 CB A:CYS61 3.5 0.0 1.0 HG13 A:ILE63 3.5 0.0 1.0 HB3 A:CYS61 3.6 0.0 1.0 HB A:ILE63 3.8 0.0 1.0 HB2 A:CYS67 3.8 0.0 1.0 HE1 A:HIS80 3.8 0.0 1.0 HB2 A:CYS61 3.8 0.0 1.0 HD2 A:HIS85 3.8 0.0 1.0 CG A:HIS80 3.8 0.0 1.0 CG A:HIS85 3.9 0.0 1.0 HB2 A:ARG69 4.1 0.0 1.0 ND1 A:HIS80 4.2 0.0 1.0 H A:ILE63 4.2 0.0 1.0 HD1 A:HIS85 4.2 0.0 1.0 HA A:ILE81 4.2 0.0 1.0 CG1 A:ILE63 4.3 0.0 1.0 HG12 A:ILE63 4.3 0.0 1.0 CD1 A:ILE81 4.3 0.0 1.0 O A:CYS67 4.4 0.0 1.0 H A:ARG69 4.4 0.0 1.0 HD11 A:ILE81 4.5 0.0 1.0 CA A:CYS67 4.5 0.0 1.0 CB A:ILE63 4.5 0.0 1.0 HD13 A:ILE81 4.6 0.0 1.0 C A:CYS67 4.7 0.0 1.0 HB2 A:ARG84 4.7 0.0 1.0 HG3 A:ARG69 4.8 0.0 1.0 HA A:CYS67 4.9 0.0 1.0 CA A:CYS61 4.9 0.0 1.0 H A:VAL64 4.9 0.0 1.0 HG22 A:ILE81 5.0 0.0 1.0 N A:ILE63 5.0 0.0 1.0 C A:CYS61 5.0 0.0 1.0

M.Mukherjee, F.Jing-Song, S.Ramachandran, G.R.Guy, J.Sivaraman. Dimeric Switch of Hakai-Truncated Monomers During Substrate Recognition: Insights From Solution Studies and uc(Nmr) Structure J.Biol.Chem. 2014.
ISSN: ESSN 1083-351X
DOI: 10.1074/JBC.M114.592840