Zinc in PDB 9fux: Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P)

All present enzymatic activity of Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P):
2.1.1.375; 2.7.7.48; 2.7.7.88;

The binding sites of Zinc atom in the Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P) (pdb code 9fux). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P), PDB code: 9fux:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2301 b:81.8 occ:1.00 NE2 A:HIS1423 2.0 27.9 1.0 ND1 A:HIS1421 2.0 9.0 1.0 SG A:CYS1236 2.3 30.2 1.0 SG A:CYS1239 2.3 34.3 1.0 CB A:CYS1236 2.7 30.2 1.0 CG A:HIS1421 2.9 9.0 1.0 CE1 A:HIS1423 3.0 27.9 1.0 CD2 A:HIS1423 3.0 27.9 1.0 CE1 A:HIS1421 3.1 9.0 1.0 CB A:HIS1421 3.2 9.0 1.0 CB A:CYS1239 3.5 34.3 1.0 N A:CYS1239 3.9 34.3 1.0 CD2 A:HIS1421 4.1 9.0 1.0 ND1 A:HIS1423 4.1 27.9 1.0 CG A:HIS1423 4.1 27.9 1.0 NE2 A:HIS1421 4.1 9.0 1.0 CA A:CYS1239 4.2 34.3 1.0 CA A:CYS1236 4.2 30.2 1.0 CG A:TYR1246 4.6 23.3 1.0 CD1 A:TYR1246 4.6 23.3 1.0 CA A:HIS1421 4.7 9.0 1.0 C A:ILE1238 4.8 25.5 1.0 CB A:ILE1238 4.8 25.5 1.0 CD2 A:TYR1246 4.8 23.3 1.0 CD1 A:ILE1230 4.8 16.9 1.0 CE1 A:TYR1246 4.9 23.3 1.0 C A:CYS1236 4.9 30.2 1.0 CB A:TYR1246 5.0 23.3 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the Nipah Virus Polymerase (L) Bound to the Tetrameric Phosphoprotein (P) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2302 b:169.6 occ:1.00 OE2 A:GLU1223 2.2 9.7 1.0 SG A:CYS1428 2.3 48.2 1.0 SG A:CYS1191 2.3 21.9 1.0 SG A:CYS1429 2.3 32.0 1.0 CD A:GLU1223 3.1 9.7 1.0 CB A:CYS1191 3.3 21.9 1.0 O A:CYS1428 3.3 48.2 1.0 C A:CYS1428 3.4 48.2 1.0 CB A:CYS1428 3.5 48.2 1.0 CB A:CYS1429 3.7 32.0 1.0 CA A:CYS1191 3.8 21.9 1.0 CG A:GLU1223 3.8 9.7 1.0 N A:CYS1429 3.9 32.0 1.0 CA A:CYS1428 3.9 48.2 1.0 OE1 A:GLU1223 4.0 9.7 1.0 CA A:CYS1429 4.0 32.0 1.0 N A:SER1192 4.2 9.0 1.0 OG A:SER1192 4.5 9.0 1.0 C A:CYS1191 4.5 21.9 1.0 CB A:GLU1223 4.6 9.7 1.0 O A:GLU1223 4.9 9.7 1.0

E.Balikci, F.Gunl, L.Carrique, J.R.Keown, E.Fodor, J.M.Grimes. Structure of the Nipah Virus Polymerase Complex. Embo J. 2024.
ISSN: ESSN 1460-2075
PubMed: 39739115
DOI: 10.1038/S44318-024-00321-Z