Zinc in PDB 8zvp: Human SIRT6 in Complex with Egcg

All present enzymatic activity of Human SIRT6 in Complex with Egcg:
2.3.1.286;

The structure of Human SIRT6 in Complex with Egcg, PDB code: 8zvp was solved by B.Song, Y.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.60 / 2.50
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	91.2, 91.2, 143.71, 90, 90, 120
R / Rfree (%)	14.8 / 20.5

The binding sites of Zinc atom in the Human SIRT6 in Complex with Egcg (pdb code 8zvp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human SIRT6 in Complex with Egcg, PDB code: 8zvp:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human SIRT6 in Complex with Egcg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SIRT6 in Complex with Egcg within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:93.0 occ:1.00 CB A:CYS144 2.1 71.9 1.0 SG A:CYS166 2.3 94.3 1.0 SG A:CYS141 2.3 76.6 1.0 SG A:CYS177 2.6 84.9 1.0 CB A:CYS166 3.1 76.9 1.0 CB A:CYS141 3.1 66.9 1.0 SG A:CYS144 3.2 94.0 1.0 CA A:CYS144 3.2 73.0 1.0 N A:CYS144 3.3 77.5 1.0 CB A:CYS177 3.6 82.8 1.0 OG1 A:THR146 4.1 78.2 1.0 C A:CYS144 4.4 67.3 1.0 CA A:CYS166 4.5 67.8 1.0 C A:LYS143 4.5 83.8 1.0 CA A:CYS141 4.6 59.9 1.0 CG2 A:VAL168 4.7 86.8 1.0 CB A:LYS143 4.7 90.7 1.0 N A:LYS145 4.8 76.7 1.0 CB A:THR146 4.8 65.4 1.0 N A:GLY179 5.0 83.1 1.0 CB A:VAL168 5.0 90.0 1.0

Zinc binding site 2 out of 2 in the Human SIRT6 in Complex with Egcg


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human SIRT6 in Complex with Egcg within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:88.6 occ:1.00 SG B:CYS144 2.2 89.8 1.0 SG B:CYS141 2.2 96.5 1.0 SG B:CYS166 2.7 99.0 1.0 CB B:CYS141 2.9 84.1 1.0 SG B:CYS177 3.0 92.9 1.0 N B:CYS144 3.2 92.4 1.0 CB B:CYS144 3.2 92.7 1.0 CB B:CYS166 3.3 80.7 1.0 CA B:CYS144 3.6 84.0 1.0 C B:LYS143 4.3 104.5 1.0 CB B:CYS177 4.3 84.9 1.0 C B:CYS144 4.3 81.1 1.0 CA B:CYS141 4.3 78.7 1.0 CB B:LYS143 4.5 97.1 1.0 N B:LYS145 4.5 83.5 1.0 CB B:THR146 4.6 73.1 1.0 CA B:LYS143 4.6 97.5 1.0 N B:LYS143 4.6 98.5 1.0 N B:THR146 4.7 72.7 1.0 CA B:CYS166 4.8 75.7 1.0 C B:CYS141 4.9 77.3 1.0 CG2 B:VAL168 5.0 81.1 1.0 OG1 B:THR146 5.0 72.6 1.0

B.Song, Y.Wang. SIRT6 in Complex with Egcg To Be Published.