Zinc in PDB 8vrt: The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant

All present enzymatic activity of The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant:
3.5.1.98;

The binding sites of Zinc atom in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant (pdb code 8vrt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant, PDB code: 8vrt:

Zinc binding site 1 out of 1 in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4R313PRR Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn500 b:31.2 occ:1.00 OD1 C:ASP176 2.2 16.3 1.0 OD2 C:ASP264 2.2 13.4 1.0 ND1 C:HIS178 2.3 14.6 1.0 OD2 C:ASP176 2.5 17.9 1.0 CG C:ASP176 2.6 15.5 1.0 CE1 C:HIS178 3.0 13.8 1.0 CG C:ASP264 3.2 13.3 1.0 CG C:HIS178 3.5 14.3 1.0 OD1 C:ASP264 3.7 16.1 1.0 CB C:HIS178 3.9 14.4 1.0 CB C:ASP176 4.1 13.5 1.0 CA C:GLY301 4.2 14.7 1.0 N C:HIS178 4.2 14.3 1.0 OH C:TYR303 4.3 20.1 1.0 NE2 C:HIS178 4.3 13.6 1.0 CB C:ASP264 4.5 13.2 1.0 CD2 C:HIS178 4.5 14.9 1.0 CG2 C:ILE177 4.5 13.9 1.0 NE2 C:HIS140 4.6 17.8 1.0 N C:ILE177 4.7 13.8 1.0 CA C:HIS178 4.7 14.2 1.0 NE2 C:HIS141 4.8 20.7 1.0 CE2 C:TYR303 4.8 20.3 1.0 CZ C:TYR303 4.9 20.0 1.0

X.Xie, B.Liau, N.Zheng. Molecular Mechanism Underlying KBTBD4 Cancer Mutation-Driven Degradation of Hdac Corepressor Complexes To Be Published.