Zinc in PDB 8vjx: Structure of Human Neurolysin in Complex with Bradykinin Peptide

All present enzymatic activity of Structure of Human Neurolysin in Complex with Bradykinin Peptide:
3.4.24.16;

The structure of Structure of Human Neurolysin in Complex with Bradykinin Peptide, PDB code: 8vjx was solved by K.Shi, H.Aihara, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	96.56 / 2.89
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	143.826, 60.51, 96.558, 90, 90, 90
R / Rfree (%)	22.3 / 25.5

The binding sites of Zinc atom in the Structure of Human Neurolysin in Complex with Bradykinin Peptide (pdb code 8vjx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Neurolysin in Complex with Bradykinin Peptide, PDB code: 8vjx:

Zinc binding site 1 out of 1 in the Structure of Human Neurolysin in Complex with Bradykinin Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Neurolysin in Complex with Bradykinin Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:191.5 occ:1.00 OE1 A:GLU503 2.1 161.1 1.0 NE2 A:HIS478 2.1 137.7 1.0 O C:GLY4 2.1 162.4 0.5 O C:GLY4 2.2 162.4 0.5 OE2 A:GLU503 2.3 149.4 1.0 CD A:GLU503 2.5 140.1 1.0 NE2 A:HIS474 2.6 58.0 1.0 CD2 A:HIS478 3.0 143.2 1.0 CE1 A:HIS478 3.2 147.6 1.0 C C:GLY4 3.4 141.6 0.5 C C:GLY4 3.4 141.4 0.5 OG A:SER506 3.5 44.3 1.0 CD2 A:HIS474 3.5 57.7 1.0 CE1 A:HIS474 3.5 58.7 1.0 N C:GLY4 3.8 114.3 0.5 CB A:SER506 4.0 42.5 1.0 CG A:GLU503 4.1 112.4 1.0 OE1 A:GLU475 4.1 61.2 1.0 CG A:HIS478 4.2 139.7 1.0 CA C:GLY4 4.2 126.4 0.5 ND1 A:HIS478 4.3 143.6 1.0 N C:PHE5 4.3 134.8 1.0 CA C:GLY4 4.3 126.4 0.5 CA C:PHE5 4.4 118.5 1.0 ND1 A:HIS474 4.6 58.0 1.0 CG A:HIS474 4.6 56.8 1.0 CE1 A:TYR613 4.7 34.4 1.0 C C:PRO3 4.8 82.4 0.5 OE2 A:GLU475 4.8 61.9 1.0 CD1 C:PHE5 4.8 101.6 1.0 CD A:GLU475 4.8 60.9 1.0 CB A:GLU503 4.8 88.5 1.0 CB C:PHE5 4.9 109.8 1.0 CB C:PRO3 4.9 47.5 0.5 OH A:TYR606 4.9 50.0 1.0 CA A:GLU503 4.9 66.1 1.0 CA C:PRO3 5.0 58.2 0.5 OH A:TYR613 5.0 36.7 1.0

K.Shi, S.Bagchi, J.Bickel, S.H.Esfahani, L.Yin, T.Cheng, V.T.Karamyan, H.Aihara. Structural Basis of Divergent Substrate Recognition and Inhibition of Human Neurolysin. Sci Rep V. 14 18420 2024.
ISSN: ESSN 2045-2322
PubMed: 39117724
DOI: 10.1038/S41598-024-67639-W