Zinc in PDB 8sok: Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna

All present enzymatic activity of Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna:
2.7.7.48; 3.4.22.28; 3.4.22.29; 3.6.1.15;

The binding sites of Zinc atom in the Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna (pdb code 8sok). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna, PDB code: 8sok:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1301 b:130.7 occ:1.00 SG A:CYS1055 2.3 101.8 1.0 SG A:CYS1062 2.3 99.7 1.0 SG A:CYS1043 2.3 100.3 1.0 SG A:CYS1046 2.3 99.1 1.0 HB2 A:CYS1062 2.3 99.7 1.0 HB3 A:CYS1043 2.6 100.3 1.0 CB A:CYS1062 2.7 99.7 1.0 CB A:CYS1043 2.8 100.3 1.0 HG A:CYS1046 2.8 99.1 1.0 HB2 A:CYS1043 2.9 100.3 1.0 HB2 A:CYS1055 2.9 101.8 1.0 HG A:CYS1055 2.9 101.8 1.0 HB3 A:CYS1062 3.0 99.7 1.0 CB A:CYS1055 3.0 101.8 1.0 HB3 A:CYS1055 3.1 101.8 1.0 HG A:CYS1043 3.2 100.3 1.0 HB2 A:ARG1057 3.4 100.4 1.0 HG A:CYS1062 3.4 99.7 1.0 HB2 A:TYR1045 3.6 92.6 1.0 H A:CYS1046 3.7 99.1 1.0 CB A:CYS1046 3.9 99.1 1.0 HB3 A:CYS1046 4.1 99.1 1.0 CA A:CYS1062 4.1 99.7 1.0 N A:CYS1046 4.2 99.1 1.0 H A:TYR1045 4.2 92.6 1.0 HA A:CYS1062 4.2 99.7 1.0 H A:ARG1057 4.3 100.4 1.0 CA A:CYS1043 4.3 100.3 1.0 HG A:CYS1050 4.3 104.5 1.0 CB A:ARG1057 4.3 100.4 1.0 O A:THR1064 4.5 103.5 1.0 CA A:CYS1055 4.5 101.8 1.0 CB A:TYR1045 4.5 92.6 1.0 HB2 A:CYS1050 4.6 104.5 1.0 HB2 A:CYS1046 4.6 99.1 1.0 HG A:SER1048 4.6 102.1 1.0 CA A:CYS1046 4.6 99.1 1.0 OG A:SER1048 4.6 102.1 1.0 HG2 A:ARG1057 4.6 100.4 1.0 HB3 A:TYR1045 4.7 92.6 1.0 HA A:CYS1043 4.7 100.3 1.0 HA A:CYS1055 4.7 101.8 1.0 HA A:LEU1058 4.8 100.8 1.0 HG3 A:ARG1057 4.8 100.4 1.0 C A:CYS1043 4.8 100.3 1.0 H A:CYS1043 4.8 100.3 1.0 C A:ARG1057 4.8 100.4 1.0 O A:CYS1046 4.9 99.1 1.0 CG A:ARG1057 4.9 100.4 1.0 HB3 A:ARG1057 4.9 100.4 1.0 N A:ARG1057 4.9 100.4 1.0 N A:TYR1045 4.9 92.6 1.0 N A:LEU1058 4.9 100.8 1.0 CA A:ARG1057 4.9 100.4 1.0 C A:CYS1062 4.9 99.7 1.0 C A:TYR1045 5.0 92.6 1.0 SG A:CYS1050 5.0 104.5 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human Cst Bound to POT1(Esdl)/TPP1 in the Presence of Telomeric Ssdna within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn701 b:156.3 occ:1.00 SG D:CYS382 2.3 111.1 1.0 SG D:CYS506 2.3 116.2 1.0 SG D:CYS385 2.3 111.9 1.0 SG D:CYS503 2.3 110.9 1.0 HG D:CYS382 2.7 111.1 1.0 HB3 D:CYS382 3.0 111.1 1.0 HG D:CYS503 3.1 110.9 1.0 CB D:CYS382 3.2 111.1 1.0 HG D:CYS385 3.2 111.9 1.0 HB3 D:CYS503 3.2 110.9 1.0 HB2 D:CYS506 3.2 116.2 1.0 CB D:CYS503 3.3 110.9 1.0 HG D:CYS506 3.3 116.2 1.0 H D:CYS385 3.4 111.9 1.0 HB2 D:CYS503 3.4 110.9 1.0 HB2 D:CYS382 3.4 111.1 1.0 CB D:CYS506 3.4 116.2 1.0 HB3 D:CYS385 3.5 111.9 1.0 CB D:CYS385 3.6 111.9 1.0 HB3 D:GLN505 3.7 107.9 1.0 H D:CYS506 3.9 116.2 1.0 HB3 D:LYS384 4.0 112.4 1.0 HB3 D:CYS506 4.1 116.2 1.0 N D:CYS385 4.1 111.9 1.0 N D:CYS506 4.2 116.2 1.0 HB2 D:CYS385 4.3 111.9 1.0 CA D:CYS385 4.4 111.9 1.0 CA D:CYS506 4.4 116.2 1.0 CA D:CYS382 4.6 111.1 1.0 CB D:GLN505 4.6 107.9 1.0 CA D:CYS503 4.7 110.9 1.0 HG12 D:VAL536 4.8 112.9 1.0 HG2 D:GLN505 4.8 107.9 1.0 HA D:CYS506 4.8 116.2 1.0 H D:GLN505 4.8 107.9 1.0 C D:GLN505 4.9 107.9 1.0 O D:CYS382 4.9 111.1 1.0 C D:CYS382 4.9 111.1 1.0 HA D:CYS382 4.9 111.1 1.0 CB D:LYS384 5.0 112.4 1.0 H D:LYS384 5.0 112.4 1.0 HB3 D:LEU387 5.0 101.1 1.0 HA D:CYS503 5.0 110.9 1.0

S.W.Cai, H.Takai, T.Walz, T.De Lange. Structural Basis of Cst-Pol Alpha /Primase Recruitment and Regulation By POT1 at Telomeres. Biorxiv 2023.
ISSN: ISSN 2692-8205
PubMed: 37215005
DOI: 10.1101/2023.05.08.539880