Zinc in PDB 8jhz: Cryo-Em Structure of the Tcsh-TMPRSS2 Complex

All present enzymatic activity of Cryo-Em Structure of the Tcsh-TMPRSS2 Complex:
3.4.21.122;

The binding sites of Zinc atom in the Cryo-Em Structure of the Tcsh-TMPRSS2 Complex (pdb code 8jhz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cryo-Em Structure of the Tcsh-TMPRSS2 Complex, PDB code: 8jhz:

Zinc binding site 1 out of 1 in the Cryo-Em Structure of the Tcsh-TMPRSS2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the Tcsh-TMPRSS2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn3000 b:83.4 occ:1.00 NE2 A:HIS759 1.8 82.8 1.0 ND1 A:HIS655 1.9 57.4 1.0 SG A:CYS700 2.2 54.9 1.0 CE1 A:HIS759 2.7 82.8 1.0 CD2 A:HIS759 2.8 82.8 1.0 CE1 A:HIS655 2.8 57.4 1.0 OD2 A:ASP545 2.8 81.0 1.0 CG A:HIS655 2.9 57.4 1.0 CB A:HIS655 3.3 57.4 1.0 CB A:CYS700 3.4 54.9 1.0 CG A:ASP545 3.6 81.0 1.0 ND1 A:HIS759 3.8 82.8 1.0 NE2 A:HIS655 3.9 57.4 1.0 CG A:HIS759 3.9 82.8 1.0 CD2 A:HIS655 3.9 57.4 1.0 CB A:ASP545 4.0 81.0 1.0 CA A:HIS655 4.2 57.4 1.0 OD1 A:ASP545 4.4 81.0 1.0 OE2 A:GLU544 4.5 81.8 1.0 CG A:GLU544 4.5 81.8 1.0 CA A:CYS700 4.6 54.9 1.0 N A:CYS700 4.6 54.9 1.0 CD A:GLU544 4.8 81.8 1.0 N A:GLY656 4.9 52.5 1.0 C A:HIS655 5.0 57.4 1.0

R.Zhou, L.He, J.Zhang, X.Zhang, Y.Li, X.Zhan, L.Tao. Molecular Basis of TMPRSS2 Recognition By Paeniclostridium Sordellii Hemorrhagic Toxin. Nat Commun V. 15 1976 2024.
ISSN: ESSN 2041-1723
PubMed: 38438396
DOI: 10.1038/S41467-024-46394-6