Zinc in PDB 8gcr: HPV16 E6-E6AP-P53 Complex

All present enzymatic activity of HPV16 E6-E6AP-P53 Complex:
2.3.2.26;

The binding sites of Zinc atom in the HPV16 E6-E6AP-P53 Complex (pdb code 8gcr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the HPV16 E6-E6AP-P53 Complex, PDB code: 8gcr:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the HPV16 E6-E6AP-P53 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of HPV16 E6-E6AP-P53 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn500 b:17.4 occ:1.00 SG A:CYS40 2.3 5.9 1.0 SG A:CYS73 2.3 3.6 1.0 SG A:CYS37 2.3 5.4 1.0 SG A:CYS70 2.3 3.4 1.0 CB A:CYS37 3.2 5.4 1.0 CB A:CYS73 3.4 3.6 1.0 CB A:CYS40 3.4 5.9 1.0 N A:CYS40 3.7 5.9 1.0 CB A:CYS70 3.7 3.4 1.0 CA A:CYS40 4.1 5.9 1.0 N A:CYS70 4.1 3.4 1.0 N A:CYS73 4.3 3.6 1.0 CA A:CYS73 4.4 3.6 1.0 CB A:TYR39 4.5 4.8 1.0 CA A:CYS70 4.5 3.4 1.0 CA A:CYS37 4.7 5.4 1.0 C A:TYR39 4.8 4.8 1.0 C A:CYS40 4.8 5.9 1.0 N A:TYR39 4.9 4.8 1.0 CA A:TYR39 5.0 4.8 1.0 C A:CYS70 5.0 3.4 1.0

Zinc binding site 2 out of 3 in the HPV16 E6-E6AP-P53 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of HPV16 E6-E6AP-P53 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn501 b:20.9 occ:1.00 SG A:CYS110 2.3 4.6 1.0 SG A:CYS113 2.3 4.8 1.0 SG A:CYS146 2.3 16.9 1.0 SG A:CYS143 2.3 13.1 1.0 CB A:CYS146 3.2 16.9 1.0 CB A:CYS110 3.2 4.6 1.0 CB A:CYS113 3.6 4.8 1.0 CB A:CYS143 3.8 13.1 1.0 N A:CYS113 4.0 4.8 1.0 N A:CYS146 4.1 16.9 1.0 CA A:CYS146 4.3 16.9 1.0 N A:CYS143 4.3 13.1 1.0 CA A:CYS113 4.3 4.8 1.0 CA A:CYS143 4.6 13.1 1.0 CA A:CYS110 4.7 4.6 1.0 CB A:SER145 4.8 20.9 1.0 O A:CYS143 4.9 13.1 1.0 CB A:ASN112 5.0 5.5 1.0 N A:ASN112 5.0 5.5 1.0 C A:CYS113 5.0 4.8 1.0

Zinc binding site 3 out of 3 in the HPV16 E6-E6AP-P53 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of HPV16 E6-E6AP-P53 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn500 b:54.3 occ:1.00 NE2 B:HIS179 2.1 43.3 1.0 CB B:CYS176 2.2 44.7 1.0 SG B:CYS242 2.3 39.5 1.0 SG B:CYS176 2.3 44.7 1.0 SG B:CYS238 2.3 35.7 1.0 CD2 B:HIS179 2.4 43.3 1.0 CB B:CYS238 3.0 35.7 1.0 CB B:CYS242 3.3 39.5 1.0 CE1 B:HIS179 3.4 43.3 1.0 CA B:CYS176 3.7 44.7 1.0 CA B:CYS238 3.7 35.7 1.0 CG B:HIS179 3.8 43.3 1.0 ND1 B:HIS179 4.2 43.3 1.0 N B:CYS176 4.2 44.7 1.0 C B:CYS176 4.4 44.7 1.0 N B:ASN239 4.4 34.5 1.0 CA B:CYS242 4.6 39.5 1.0 C B:CYS238 4.6 35.7 1.0 O B:CYS176 4.6 44.7 1.0 CB B:HIS178 4.7 44.2 1.0 O B:MET237 4.9 32.7 1.0 N B:CYS238 4.9 35.7 1.0 ND1 B:HIS178 5.0 44.2 1.0 CB B:HIS179 5.0 43.3 1.0

J.C.K.Wang, H.T.Baddock, A.Mafi, I.T.Foe, M.Bratkowski, T.Y.Lin, Z.D.Jensvold, M.Preciado Lopez, D.Stokoe, D.Eaton, Q.Hao, A.H.Nile. Structure of the P53 Degradation Complex From HPV16. Nat Commun V. 15 1842 2024.
ISSN: ESSN 2041-1723
PubMed: 38418456
DOI: 10.1038/S41467-024-45920-W