Zinc in PDB 8d7y: Cereblon-DDB1 in the Apo Form with DDB1 in the Twisted Conformation

The binding sites of Zinc atom in the Cereblon-DDB1 in the Apo Form with DDB1 in the Twisted Conformation (pdb code 8d7y). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cereblon-DDB1 in the Apo Form with DDB1 in the Twisted Conformation, PDB code: 8d7y:

Zinc binding site 1 out of 1 in the Cereblon-DDB1 in the Apo Form with DDB1 in the Twisted Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cereblon-DDB1 in the Apo Form with DDB1 in the Twisted Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:502.8 occ:1.00 SG B:CYS394 1.7 278.3 1.0 CB B:CYS394 2.6 278.3 1.0 SG B:CYS323 2.7 249.7 1.0 CB B:CYS323 3.0 249.7 1.0 CB B:CYS391 3.1 285.8 1.0 CB B:CYS326 3.5 248.1 1.0 SG B:CYS391 3.6 285.8 1.0 O B:LYS324 4.0 224.2 1.0 CA B:CYS394 4.1 278.3 1.0 N B:CYS326 4.4 248.1 1.0 CA B:CYS323 4.5 249.7 1.0 N B:CYS394 4.5 278.3 1.0 CA B:CYS391 4.5 285.8 1.0 CA B:CYS326 4.6 248.1 1.0 SG B:CYS326 4.6 248.1 1.0 N B:CYS391 4.8 285.8 1.0 C B:CYS394 4.8 278.3 1.0

E.R.Watson, S.Novick, M.E.Matyskiela, P.P.Chamberlain, A.H De La Pena, J.Zhu, E.Tran, P.R.Griffin, I.E.Wertz, G.C.Lander. Molecular Glue Celmod Compounds Are Regulators of Cereblon Conformation. Science V. 378 549 2022.
ISSN: ESSN 1095-9203
PubMed: 36378961
DOI: 10.1126/SCIENCE.ADD7574