Zinc in PDB 8cvp: Cereblon-DDB1 in the Apo Form

The binding sites of Zinc atom in the Cereblon-DDB1 in the Apo Form (pdb code 8cvp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Cereblon-DDB1 in the Apo Form, PDB code: 8cvp:

Zinc binding site 1 out of 1 in the Cereblon-DDB1 in the Apo Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cereblon-DDB1 in the Apo Form within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn501 b:301.0 occ:1.00 CB B:CYS326 2.3 164.0 1.0 SG B:CYS394 2.3 187.9 1.0 SG B:CYS391 2.3 184.7 1.0 SG B:CYS323 2.3 157.3 1.0 SG B:CYS326 2.3 164.0 1.0 CB B:CYS323 3.0 157.3 1.0 CB B:CYS391 3.5 184.7 1.0 CB B:CYS394 3.6 187.9 1.0 CA B:CYS326 3.8 164.0 1.0 N B:CYS394 4.2 187.9 1.0 CB B:ILE393 4.2 183.6 1.0 CB B:THR329 4.3 139.7 1.0 CA B:CYS323 4.5 157.3 1.0 N B:CYS326 4.5 164.0 1.0 C B:ILE393 4.5 183.6 1.0 CA B:CYS394 4.5 187.9 1.0 C B:CYS326 4.7 164.0 1.0 CA B:ILE393 4.8 183.6 1.0 N B:ILE393 4.8 183.6 1.0 CA B:CYS391 4.9 184.7 1.0 C B:CYS323 5.0 157.3 1.0 O B:GLN325 5.0 142.0 1.0 C B:GLN325 5.0 142.0 1.0

E.R.Watson, S.J.Novick, M.E.Matyskiela, P.P.Chamberlain, A.H.De La Pena, J.Y.Zhu, E.Tran, P.R.Griffin, I.E.Wertz, G.C.Lander. Molecular Glue Celmod Compounds Are Allosteric Regulators of Cereblon Conformation Biorxiv 2022.
DOI: 10.1101/2022.07.02.498551