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Zinc in PDB 8c8w: Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue

Enzymatic activity of Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue

All present enzymatic activity of Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue:
6.1.1.5;

Protein crystallography data

The structure of Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue, PDB code: 8c8w was solved by A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.31 / 2.29
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 107.92, 107.92, 239.36, 90, 90, 90
R / Rfree (%) 19.9 / 23.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue (pdb code 8c8w). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue, PDB code: 8c8w:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8c8w

Go back to Zinc Binding Sites List in 8c8w
Zinc binding site 1 out of 2 in the Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn4103

b:51.2
occ:1.00
 SG A:CYS500 2.3 47.4 1.0
SG A:CYS462 2.3 49.5 1.0
SG A:CYS459 2.3 46.3 1.0
SG A:CYS503 2.3 56.2 1.0
CB A:CYS500 3.1 47.8 1.0
CB A:CYS459 3.2 39.3 1.0
CB A:CYS503 3.5 48.4 1.0
CB A:CYS462 3.6 47.8 1.0
N A:CYS462 3.7 55.0 1.0
N A:CYS503 3.7 55.4 1.0
CA A:CYS503 4.1 53.8 1.0
CA A:CYS462 4.2 60.9 1.0
CB A:VAL502 4.4 61.0 1.0
N A:GLY505 4.4 44.9 1.0
CB A:HIS464 4.5 39.7 1.0
CA A:CYS500 4.6 49.0 1.0
CA A:CYS459 4.6 45.7 1.0
C A:CYS503 4.6 49.3 1.0
C A:GLY461 4.7 58.0 1.0
C A:CYS462 4.7 49.4 1.0
N A:SER504 4.8 61.0 1.0
C A:VAL502 4.8 63.8 1.0
CA A:GLY505 4.8 43.1 1.0
CA A:GLY461 4.8 47.6 1.0
CG1 A:VAL502 4.8 46.6 1.0
N A:GLY461 4.9 58.8 1.0
N A:HIS464 4.9 49.1 1.0
N A:GLN463 4.9 53.1 1.0
N A:VAL502 5.0 57.8 1.0
CA A:VAL502 5.0 57.9 1.0

Zinc binding site 2 out of 2 in 8c8w

Go back to Zinc Binding Sites List in 8c8w
Zinc binding site 2 out of 2 in the Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Priestia Megaterium Mupirocin Hyper-Resistant High Motif Mutant of Type 2 Isoleucyl-Trna Synthetase Complexed with An Isoleucyl- Adenylate Analogue within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn4104

b:52.3
occ:1.00
 SG A:CYS181 2.3 48.5 1.0
SG A:CYS387 2.3 54.6 1.0
SG A:CYS390 2.3 75.0 1.0
SG A:CYS184 2.3 53.6 1.0
CB A:CYS387 3.1 47.3 1.0
CB A:CYS184 3.2 49.2 1.0
CB A:CYS390 3.5 47.6 1.0
CB A:CYS181 3.5 49.9 1.0
N A:CYS184 3.7 62.5 1.0
O A:HOH4268 4.0 54.6 1.0
N A:CYS390 4.0 47.7 1.0
CA A:CYS184 4.1 50.3 1.0
CA A:CYS390 4.3 56.1 1.0
CA A:CYS387 4.6 52.9 1.0
CB A:SER183 4.6 45.0 1.0
C A:SER183 4.8 63.4 1.0
CA A:CYS181 4.9 61.2 1.0
CB A:SER392 4.9 51.7 1.0
C A:CYS390 4.9 62.8 1.0
CD1 A:LEU93 5.0 46.0 1.0

Reference:

A.Brkic, M.Leibundgut, J.Jablonska, V.Zanki, Z.Car, V.Petrovic Perokovic, N.Ban, I.Gruic-Sovulj. Antibiotic Hyper-Resistance in A Class I Aminoacyl-Trna Synthetase with Altered Active Site Signature Motif To Be Published.
Page generated: Fri Aug 22 08:51:27 2025

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