Zinc in PDB 7trl: Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3

All present enzymatic activity of Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3:
2.3.2.27;

The structure of Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3, PDB code: 7trl was solved by B.J.Klein, A.H.Tencer, T.G.Kutateladze, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.58 / 1.74
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	33.655, 34.972, 35.605, 90, 103.87, 90
R / Rfree (%)	16.2 / 20.6

The binding sites of Zinc atom in the Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3 (pdb code 7trl). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3, PDB code: 7trl:

Zinc binding site 1 out of 1 in the Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human BIRC2 BIR3 Domain in Complex with Histone H3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn407 b:17.6 occ:1.00 NE2 A:HIS326 2.0 15.0 1.0 SG A:CYS309 2.3 15.0 1.0 SG A:CYS333 2.4 15.7 1.0 SG A:CYS306 2.4 14.4 1.0 CE1 A:HIS326 2.9 15.2 1.0 CB A:CYS333 3.1 15.0 1.0 CB A:CYS306 3.1 16.4 1.0 CD2 A:HIS326 3.2 17.1 1.0 CB A:CYS309 3.2 16.8 1.0 N A:CYS309 3.6 17.0 1.0 CA A:CYS309 4.0 18.6 1.0 ND1 A:HIS326 4.1 16.5 1.0 CG A:HIS326 4.2 16.0 1.0 CA A:CYS333 4.4 13.5 1.0 CB A:CYS308 4.4 14.7 1.0 CA A:CYS306 4.6 13.3 1.0 C A:CYS308 4.7 18.0 1.0 CB A:PHE330 4.8 15.2 1.0 C A:CYS309 4.9 18.3 1.0 CA A:CYS308 5.0 17.1 1.0 N A:CYS308 5.0 14.2 1.0

A.H.Tencer, Y.Yu, S.Z.Causse, G.R.Campbell, B.J.Klein, H.Xuan, J.Cartier, M.A.Miles, N.Gaurav, A.Zadoroznyj, T.A.Holt, H.Wen, C.J.Hawkins, S.A.Spector, L.Dubrez, X.Shi, T.G.Kutateladze. Molecular Basis For Nuclear Accumulation and Targeting of the Inhibitor of Apoptosis BIRC2 Nat.Struct.Mol.Biol. 2023.
ISSN: ESSN 1545-9985
DOI: 10.1038/S41594-023-01044-1