Zinc in PDB 7tql: Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B.

All present enzymatic activity of Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B.:
3.6.5.3; 4.2.99.18;

The binding sites of Zinc atom in the Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B. (pdb code 7tql). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B., PDB code: 7tql:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B. within 5.0Å range: probe atom residue distance (Å) B Occ c:Zn201 b:128.3 occ:1.00 SG c:CYS77 2.3 105.9 1.0 SG c:CYS74 2.3 121.8 1.0 SG c:CYS23 2.3 120.0 1.0 CB c:CYS23 3.2 116.3 1.0 CB c:CYS77 3.3 98.9 1.0 CB c:CYS26 3.4 113.0 1.0 CB c:CYS74 3.4 113.6 1.0 N c:CYS26 3.8 101.6 1.0 CA c:CYS26 4.0 106.4 1.0 CB c:ARG28 4.1 103.1 1.0 SG c:CYS26 4.1 130.9 1.0 N c:CYS74 4.2 107.2 1.0 CA c:CYS74 4.3 109.1 1.0 C c:CYS26 4.4 102.8 1.0 N c:CYS77 4.4 93.3 1.0 CA c:CYS77 4.5 93.5 1.0 N c:ARG28 4.5 97.9 1.0 N c:ALA27 4.6 99.1 1.0 CA c:CYS23 4.7 111.8 1.0 CB c:ASN25 4.8 102.6 1.0 O c:CYS74 4.8 111.5 1.0 C c:CYS74 4.9 105.9 1.0 C c:ASN25 4.9 98.8 1.0 CA c:ARG28 5.0 99.4 1.0

Zinc binding site 2 out of 3 in the Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B. within 5.0Å range: probe atom residue distance (Å) B Occ f:Zn201 b:126.7 occ:1.00 SG f:CYS42 2.3 120.4 1.0 SG f:CYS24 2.3 120.0 1.0 SG f:CYS21 2.3 112.8 1.0 CB f:CYS39 2.9 101.2 1.0 CB f:CYS21 3.3 107.4 1.0 CB f:CYS42 3.3 110.3 1.0 CB f:CYS24 3.4 112.9 1.0 N f:CYS24 3.6 104.7 1.0 N f:CYS39 3.9 95.2 1.0 CA f:CYS39 3.9 98.0 1.0 CA f:CYS24 4.0 108.4 1.0 SG f:CYS39 4.1 110.0 1.0 CB f:VAL23 4.2 99.6 1.0 CA f:CYS42 4.5 104.9 1.0 N f:CYS42 4.6 102.5 1.0 C f:VAL23 4.7 103.4 1.0 CA f:CYS21 4.7 102.8 1.0 C f:CYS24 4.7 109.0 1.0 C f:CYS39 4.7 98.3 1.0 O f:CYS39 4.8 99.0 1.0 CA f:VAL23 4.8 100.8 1.0 O2' 2:G1495 4.8 113.1 1.0 N f:SER25 4.8 111.2 1.0 CG1 f:VAL23 4.8 98.4 1.0 N f:VAL23 4.9 99.4 1.0 CB f:ASN26 4.9 118.8 1.0

Zinc binding site 3 out of 3 in the Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryoem Structure of the Human 40S Small Ribosomal Subunit in Complex with Translation Initiation Factors EIF1A and EIF5B. within 5.0Å range: probe atom residue distance (Å) B Occ g:Zn500 b:237.5 occ:1.00 SG g:CYS141 2.3 216.7 1.0 SG g:CYS126 2.3 229.4 1.0 SG g:CYS144 2.3 222.6 1.0 SG g:CYS121 2.3 231.7 1.0 OG g:SER123 3.2 208.9 1.0 CB g:CYS126 3.3 226.2 1.0 CB g:CYS141 3.3 210.0 1.0 CB g:CYS144 3.4 211.4 1.0 CB g:CYS121 3.4 223.0 1.0 N g:CYS144 4.1 199.1 1.0 CA g:CYS144 4.4 203.3 1.0 CB g:SER123 4.4 208.3 1.0 CG1 g:VAL130 4.6 221.9 1.0 CA g:CYS126 4.7 224.2 1.0 CA g:CYS141 4.8 203.9 1.0 CA g:CYS121 4.8 216.3 1.0 CB g:LYS143 4.8 188.4 1.0

C.P.Lapointe, R.Grosely, M.Sokabe, C.Alvarado, J.Wang, E.Montabana, N.Villa, B.S.Shin, T.E.Dever, C.S.Fraser, I.S.Fernandez, J.D.Puglisi. EIF5B and EIF1A Reorient Initiator Trna to Allow Ribosomal Subunit Joining. Nature V. 607 185 2022.
ISSN: ESSN 1476-4687
PubMed: 35732735
DOI: 10.1038/S41586-022-04858-Z