Zinc in PDB 7q4d: Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme

All present enzymatic activity of Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme:
3.4.15.1;

The binding sites of Zinc atom in the Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme (pdb code 7q4d). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme, PDB code: 7q4d:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1301 b:123.3 occ:1.00 OE1 A:GLU389 1.9 73.7 1.0 OE2 A:GLU389 2.1 73.7 1.0 CD A:GLU389 2.3 73.7 1.0 NE2 A:HIS365 2.3 70.9 1.0 CE1 A:HIS365 3.1 70.9 1.0 HE1 A:HIS365 3.2 70.9 1.0 CD2 A:HIS365 3.5 70.9 1.0 CG A:GLU389 3.7 73.7 1.0 HD2 A:HIS365 3.7 70.9 1.0 HG2 A:GLU389 3.9 73.7 1.0 HG3 A:GLU389 4.1 73.7 1.0 HA A:GLU389 4.2 73.7 1.0 HD1 A:HIS361 4.3 79.0 1.0 ND1 A:HIS365 4.3 70.9 1.0 CG A:HIS365 4.5 70.9 1.0 OE1 A:GLU362 4.5 79.9 1.0 ND1 A:HIS361 4.6 79.0 1.0 HB2 A:HIS361 4.6 79.0 1.0 OE2 A:GLU362 4.6 79.9 1.0 HA3 A:GLY392 4.6 73.0 1.0 HB3 A:GLU389 4.7 73.7 1.0 CB A:GLU389 4.7 73.7 1.0 CA A:GLU389 5.0 73.7 1.0 CD A:GLU362 5.0 79.9 1.0

Zinc binding site 2 out of 2 in the Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Local Refinement Structure of the Two Interacting N-Domains of Full- Length, Dimeric, Soluble Somatic Angiotensin I-Converting Enzyme within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1301 b:128.0 occ:1.00 OE1 B:GLU389 1.9 74.0 1.0 OE2 B:GLU389 2.1 74.0 1.0 CD B:GLU389 2.2 74.0 1.0 NE2 B:HIS365 2.3 71.0 1.0 CE1 B:HIS365 3.1 71.0 1.0 HE1 B:HIS365 3.2 71.0 1.0 CD2 B:HIS365 3.5 71.0 1.0 CG B:GLU389 3.7 74.0 1.0 HD2 B:HIS365 3.7 71.0 1.0 HG2 B:GLU389 3.9 74.0 1.0 HG3 B:GLU389 4.1 74.0 1.0 HD1 B:HIS361 4.2 80.4 1.0 HA B:GLU389 4.2 74.0 1.0 ND1 B:HIS365 4.3 71.0 1.0 OE2 B:GLU362 4.5 81.5 1.0 ND1 B:HIS361 4.5 80.4 1.0 CG B:HIS365 4.5 71.0 1.0 HB2 B:HIS361 4.7 80.4 1.0 HB3 B:GLU389 4.7 74.0 1.0 CB B:GLU389 4.7 74.0 1.0 OE1 B:GLU362 4.7 81.5 1.0 HA3 B:GLY392 4.7 71.8 1.0 CE1 B:HIS361 4.9 80.4 1.0 CA B:GLU389 5.0 74.0 1.0 CD B:GLU362 5.0 81.5 1.0 HE1 B:HIS361 5.0 80.4 1.0

L.Lubbe, B.T.Sewell, J.D.Woodward, E.D.Sturrock. Cryo-Em Reveals Mechanisms of Angiotensin I-Converting Enzyme Allostery and Dimerization. Embo J. V. 41 10550 2022.
ISSN: ESSN 1460-2075
PubMed: 35818993
DOI: 10.15252/EMBJ.2021110550