Zinc in PDB 7q3l: Human 17S U2 Snrnp 5' Domain

Enzymatic activity of Human 17S U2 Snrnp 5' Domain

All present enzymatic activity of Human 17S U2 Snrnp 5' Domain:
3.6.4.13;

Zinc Binding Sites:

The binding sites of Zinc atom in the Human 17S U2 Snrnp 5' Domain (pdb code 7q3l). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Human 17S U2 Snrnp 5' Domain, PDB code: 7q3l:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 7q3l

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Zinc binding site 1 out of 4 in the Human 17S U2 Snrnp 5' Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human 17S U2 Snrnp 5' Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn201

b:42.5
occ:1.00
 SG G:CYS33 2.3 53.1 1.0
SG G:CYS72 2.3 37.1 1.0
SG G:CYS75 2.3 39.3 1.0
SG G:CYS30 2.3 46.0 1.0
CB G:CYS33 3.0 53.1 1.0
CB G:CYS30 3.3 47.5 1.0
CB G:CYS72 3.5 38.1 1.0
CB G:CYS75 3.5 38.7 1.0
N G:CYS33 3.6 53.0 1.0
CA G:CYS33 3.9 53.9 1.0
N G:CYS72 4.1 38.3 1.0
N G:CYS75 4.3 39.7 1.0
CA G:CYS72 4.4 38.6 1.0
CA G:CYS75 4.5 39.0 1.0
CB G:ILE32 4.6 51.4 1.0
C G:ILE32 4.6 51.9 1.0
C G:CYS33 4.7 55.0 1.0
CA G:CYS30 4.7 48.7 1.0
N G:ASP34 4.9 56.8 1.0
C G:CYS72 5.0 39.0 1.0
CA G:ILE32 5.0 51.5 1.0

Zinc binding site 2 out of 4 in 7q3l

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Zinc binding site 2 out of 4 in the Human 17S U2 Snrnp 5' Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human 17S U2 Snrnp 5' Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn202

b:48.9
occ:1.00
 SG G:CYS85 2.1 48.3 1.0
SG G:CYS11 2.2 61.9 1.0
SG G:CYS49 2.4 74.5 1.0
SG G:CYS46 2.4 54.4 1.0
CB G:CYS85 3.1 50.0 1.0
CB G:CYS11 3.3 62.8 1.0
CB G:CYS49 3.4 75.3 1.0
CB G:CYS46 3.6 55.0 1.0
N G:CYS46 4.0 53.9 1.0
O G:CYS85 4.1 52.4 1.0
CB G:LYS87 4.2 60.8 1.0
CA G:CYS46 4.3 55.5 1.0
CA G:CYS85 4.4 51.1 1.0
N G:CYS49 4.6 74.5 1.0
CA G:CYS49 4.6 76.5 1.0
C G:CYS85 4.6 51.5 1.0
CB G:LYS13 4.6 59.4 1.0
CA G:CYS11 4.7 63.3 1.0
O G:CYS46 4.8 57.3 1.0
C G:CYS46 4.9 57.1 1.0
CG G:LYS87 5.0 61.9 1.0

Zinc binding site 3 out of 4 in 7q3l

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Zinc binding site 3 out of 4 in the Human 17S U2 Snrnp 5' Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human 17S U2 Snrnp 5' Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn203

b:83.4
occ:1.00
 SG G:CYS23 2.0 60.9 1.0
SG G:CYS61 2.3 71.1 1.0
SG G:CYS58 2.4 74.1 1.0
SG G:CYS26 2.8 69.5 1.0
CB G:CYS26 3.3 67.2 1.0
CB G:CYS58 3.4 74.3 1.0
CB G:CYS61 3.4 70.5 1.0
CB G:CYS23 3.5 60.9 1.0
N G:CYS61 3.8 70.0 1.0
N G:CYS23 4.1 59.3 1.0
CA G:CYS61 4.1 70.7 1.0
CA G:CYS23 4.3 61.4 1.0
CE G:LYS25 4.4 76.1 1.0
N G:CYS26 4.4 68.2 1.0
CA G:CYS26 4.5 66.8 1.0
CG G:LYS25 4.5 74.1 1.0
C G:CYS61 4.7 71.1 1.0
CB G:ILE60 4.8 69.1 1.0
N G:GLY63 4.8 72.0 1.0
CA G:CYS58 4.8 74.8 1.0
C G:ILE60 4.8 69.5 1.0
N G:GLY62 4.9 71.3 1.0
O G:CYS23 4.9 63.6 1.0
C G:CYS23 4.9 63.5 1.0

Zinc binding site 4 out of 4 in 7q3l

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Zinc binding site 4 out of 4 in the Human 17S U2 Snrnp 5' Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human 17S U2 Snrnp 5' Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
9:Zn601

b:186.9
occ:1.00
 SG 9:CYS408 1.8 211.3 1.0
ND1 9:HIS431 1.9 208.1 1.0
SG 9:CYS411 2.1 211.3 1.0
CE1 9:HIS431 2.8 208.0 1.0
CE1 9:HIS425 2.8 204.0 1.0
CB 9:CYS408 2.8 211.7 1.0
ND1 9:HIS425 2.8 204.0 1.0
CG 9:HIS431 3.1 208.3 1.0
N 9:CYS411 3.3 211.1 1.0
CB 9:CYS411 3.4 211.5 1.0
CB 9:HIS431 3.6 208.7 1.0
NE2 9:HIS425 3.8 204.0 1.0
CB 9:ILE410 3.8 210.2 1.0
CA 9:CYS411 3.9 211.5 1.0
CG 9:HIS425 3.9 204.1 1.0
NE2 9:HIS431 3.9 208.0 1.0
C 9:ILE410 4.0 210.6 1.0
CD2 9:HIS431 4.1 208.2 1.0
CA 9:HIS431 4.1 209.1 1.0
CA 9:CYS408 4.1 211.9 1.0
CA 9:ILE410 4.3 210.3 1.0
CD2 9:HIS425 4.3 204.1 1.0
N 9:ILE410 4.5 210.2 1.0
C 9:CYS408 4.5 211.4 1.0
CG2 9:ILE410 4.6 210.1 1.0
O 9:CYS408 4.6 211.5 1.0
CG1 9:ILE410 4.6 209.9 1.0
N 9:HIS431 4.7 210.0 1.0
O 9:ILE410 4.8 210.6 1.0
CB 9:HIS425 4.9 204.4 1.0
OH 9:TYR416 4.9 214.0 1.0
CE1 9:PHE426 4.9 201.7 1.0
O 9:HIS425 5.0 204.7 1.0

Reference:

J.Tholen, M.Razew, F.Weis, W.P.Galej. Structural Basis of Branch Site Recognition By the Human Spliceosome. Science V. 375 50 2022.
ISSN: ESSN 1095-9203
PubMed: 34822310
DOI: 10.1126/SCIENCE.ABM4245
Page generated: Sat Apr 8 01:51:44 2023

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