Zinc in PDB 7pu7: Dna Polymerase From M. Tuberculosis

All present enzymatic activity of Dna Polymerase From M. Tuberculosis:
2.7.7.7;

The binding sites of Zinc atom in the Dna Polymerase From M. Tuberculosis (pdb code 7pu7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Dna Polymerase From M. Tuberculosis, PDB code: 7pu7:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the Dna Polymerase From M. Tuberculosis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Dna Polymerase From M. Tuberculosis within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1201 b:40.5 occ:1.00 SG A:CYS158 2.4 45.5 1.0 ND1 A:HIS107 2.6 38.5 1.0 OE1 A:GLU73 2.7 40.1 1.0 ZN A:ZN1202 3.4 25.6 1.0 CE1 A:HIS107 3.4 38.7 1.0 CG A:HIS107 3.6 38.5 1.0 CB A:CYS158 3.6 45.0 1.0 CD A:GLU73 3.8 41.0 1.0 CB A:HIS107 3.8 38.2 1.0 CE1 A:HIS48 4.3 39.7 1.0 CG A:GLU73 4.4 40.6 1.0 CE1 A:HIS14 4.5 37.6 1.0 NE2 A:HIS107 4.6 39.9 1.0 OD2 A:ASP226 4.6 52.5 1.0 CD2 A:HIS107 4.7 39.3 1.0 NE2 A:HIS14 4.8 37.5 1.0 OE2 A:GLU73 4.8 41.9 1.0 CB A:SER160 4.9 45.6 1.0 CA A:CYS158 5.0 44.4 1.0

Zinc binding site 2 out of 3 in the Dna Polymerase From M. Tuberculosis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Dna Polymerase From M. Tuberculosis within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1202 b:25.6 occ:1.00 NE2 A:HIS14 2.0 37.5 1.0 NE2 A:HIS16 2.4 35.7 1.0 CE1 A:HIS14 2.7 37.6 1.0 CE1 A:HIS16 2.8 35.3 1.0 CD2 A:HIS14 3.2 38.6 1.0 OD1 A:ASP226 3.3 51.5 1.0 ZN A:ZN1201 3.4 40.5 1.0 OE1 A:GLU73 3.4 40.1 1.0 CD A:GLU73 3.7 41.0 1.0 CD2 A:HIS16 3.7 36.6 1.0 ND1 A:HIS14 3.9 38.4 1.0 CG A:ASP226 3.9 51.3 1.0 CE1 A:HIS48 4.0 39.7 1.0 OD2 A:ASP226 4.0 52.5 1.0 ND1 A:HIS16 4.1 36.1 1.0 CG A:HIS14 4.2 39.0 1.0 OE2 A:GLU73 4.2 41.9 1.0 CG A:GLU73 4.2 40.6 1.0 NE2 A:HIS48 4.4 39.3 1.0 CG A:HIS16 4.6 36.5 1.0 CB A:GLU73 4.8 39.6 1.0 ND1 A:HIS48 4.8 39.7 1.0 CE1 A:HIS228 4.9 38.3 1.0

Zinc binding site 3 out of 3 in the Dna Polymerase From M. Tuberculosis


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Dna Polymerase From M. Tuberculosis within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1203 b:45.7 occ:1.00 OD2 A:ASP23 2.3 41.7 1.0 NE2 A:HIS228 2.5 38.4 1.0 NE2 A:HIS48 2.6 39.3 1.0 CD2 A:HIS228 3.4 37.9 1.0 CG A:ASP23 3.4 42.1 1.0 CD2 A:HIS48 3.4 39.5 1.0 CE1 A:HIS228 3.5 38.3 1.0 CE1 A:HIS48 3.7 39.7 1.0 OD1 A:ASP23 3.9 43.2 1.0 CE1 A:HIS16 4.4 35.3 1.0 CZ A:PHE258 4.6 78.5 1.0 CG A:HIS228 4.6 38.9 1.0 ND1 A:HIS228 4.6 38.2 1.0 CB A:ASP23 4.6 40.5 1.0 ND1 A:HIS16 4.6 36.1 1.0 CG A:HIS48 4.6 39.5 1.0 O A:ASP23 4.7 39.9 1.0 ND1 A:HIS48 4.7 39.7 1.0 NE2 A:HIS16 4.8 35.7 1.0

M.D.Chengalroyen, M.K.Mason, A.Borsellini, R.Tassoni, G.L.Abrahams, S.Lynch, Y.M.Ahn, J.Ambler, K.Young, B.M.Crowley, D.B.Olsen, D.F.Warner, C.E.Barry Iii, H.I.M.Boshoff, M.H.Lamers, V.Mizrahi. Dna-Dependent Binding of Nargenicin to DNAE1 Inhibits Replication in Mycobacterium Tuberculosis. Acs Infect Dis. V. 8 612 2022.
ISSN: ESSN 2373-8227
PubMed: 35143160
DOI: 10.1021/ACSINFECDIS.1C00643