Zinc in PDB 7ozv: Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G

Zinc Binding Sites:

The binding sites of Zinc atom in the Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G (pdb code 7ozv). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G, PDB code: 7ozv:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 7ozv

Go back to Zinc Binding Sites List in 7ozv
Zinc binding site 1 out of 2 in the Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2000

b:75.6
occ:1.00
ND1 A:HIS295 2.1 51.9 1.0
SG A:CYS301 2.3 55.9 1.0
SG A:CYS306 2.3 53.0 1.0
SG A:CYS310 2.3 49.2 1.0
CE1 A:HIS295 3.0 51.9 1.0
CG A:HIS295 3.1 51.9 1.0
CB A:CYS301 3.3 55.9 1.0
CA A:CYS301 3.4 55.9 1.0
CB A:HIS295 3.5 51.9 1.0
O A:CYS306 3.6 53.0 1.0
CB A:CYS306 3.6 53.0 1.0
CB A:CYS310 3.8 49.2 1.0
C A:CYS306 4.0 53.0 1.0
NE2 A:HIS295 4.1 51.9 1.0
N A:HIS295 4.1 51.9 1.0
CD2 A:HIS295 4.2 51.9 1.0
N A:CYS301 4.2 55.9 1.0
CA A:CYS306 4.3 53.0 1.0
CA A:HIS295 4.4 51.9 1.0
N A:LEU302 4.5 57.2 1.0
C A:CYS301 4.5 55.9 1.0
O A:THR293 4.5 52.7 1.0
N A:ILE307 4.8 50.0 1.0
C A:ASN300 4.8 56.0 1.0
O A:ASN300 4.9 56.0 1.0
O A:HIS295 4.9 51.9 1.0

Zinc binding site 2 out of 2 in 7ozv

Go back to Zinc Binding Sites List in 7ozv
Zinc binding site 2 out of 2 in the Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Rdrp with Molnupiravir/ Nhc in the Template Strand Base- Paired with G within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn2001

b:72.5
occ:1.00
SG A:CYS487 2.2 62.6 1.0
SG A:CYS646 2.3 60.6 1.0
SG A:CYS645 2.3 65.9 1.0
ND1 A:HIS642 2.3 59.4 1.0
CB A:CYS487 3.0 62.6 1.0
CE1 A:HIS642 3.1 59.4 1.0
CG A:HIS642 3.3 59.4 1.0
N A:CYS487 3.3 62.6 1.0
CB A:CYS645 3.6 65.9 1.0
CB A:CYS646 3.6 60.6 1.0
CB A:HIS642 3.7 59.4 1.0
CA A:CYS487 3.7 62.6 1.0
N A:CYS646 4.0 60.6 1.0
C A:CYS645 4.1 65.9 1.0
NE2 A:HIS642 4.3 59.4 1.0
CA A:CYS646 4.3 60.6 1.0
CE1 A:PHE571 4.3 55.9 1.0
CD2 A:HIS642 4.4 59.4 1.0
C A:GLY486 4.4 62.2 1.0
CA A:CYS645 4.4 65.9 1.0
O A:CYS645 4.5 65.9 1.0
CA A:HIS642 4.6 59.4 1.0
CD1 A:PHE571 4.7 55.9 1.0
CA A:GLY486 4.7 62.2 1.0
CE A:LYS532 5.0 56.0 1.0

Reference:

F.Kabinger, C.Stiller, J.Schmitzova, C.Dienemann, G.Kokic, H.S.Hillen, C.Hobartner, P.Cramer. Mechanism of Molnupiravir-Induced Sars-Cov-2 Mutagenesis Nat.Chem.Biol. 2021.
ISSN: ESSN 1552-4469
DOI: 10.1038/S41594-021-00651-0
Page generated: Sun Aug 22 09:53:06 2021

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