Zinc in PDB 7onb: Structure of the U2 5' Module of the A3'-Ssa Complex

The binding sites of Zinc atom in the Structure of the U2 5' Module of the A3'-Ssa Complex (pdb code 7onb). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure of the U2 5' Module of the A3'-Ssa Complex, PDB code: 7onb:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure of the U2 5' Module of the A3'-Ssa Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the U2 5' Module of the A3'-Ssa Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1402 b:109.8 occ:1.00 SG D:CYS46 2.3 86.3 1.0 SG D:CYS49 2.3 99.0 1.0 SG D:CYS11 2.3 81.4 1.0 SG D:CYS85 2.3 77.0 1.0 CB D:CYS11 3.1 81.4 1.0 CB D:CYS85 3.2 77.0 1.0 CB D:CYS49 3.3 99.0 1.0 CB D:CYS46 3.4 86.3 1.0 N D:CYS46 4.1 86.3 1.0 CB D:LYS87 4.1 82.0 1.0 CA D:CYS46 4.3 86.3 1.0 N D:CYS49 4.4 99.0 1.0 CA D:CYS49 4.4 99.0 1.0 CA D:CYS11 4.5 81.4 1.0 CB D:LYS13 4.6 74.5 1.0 CA D:CYS85 4.6 77.0 1.0 O D:CYS85 4.7 77.0 1.0 CD D:LYS13 4.8 74.5 1.0 CG D:LYS87 4.8 82.0 1.0 C D:CYS85 4.9 77.0 1.0 C D:CYS46 4.9 86.3 1.0 N D:LYS13 4.9 74.5 1.0 C D:CYS11 4.9 81.4 1.0 O D:CYS46 5.0 86.3 1.0 N D:LYS87 5.0 82.0 1.0

Zinc binding site 2 out of 5 in the Structure of the U2 5' Module of the A3'-Ssa Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the U2 5' Module of the A3'-Ssa Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1403 b:134.7 occ:1.00 SG D:CYS72 2.3 84.6 1.0 SG D:CYS33 2.3 90.5 1.0 SG D:CYS75 2.3 80.8 1.0 SG D:CYS30 2.3 93.8 1.0 CB D:CYS72 3.3 84.6 1.0 CB D:CYS75 3.3 80.8 1.0 CB D:CYS33 3.3 90.5 1.0 CB D:CYS30 3.4 93.8 1.0 N D:CYS33 3.7 90.5 1.0 N D:CYS72 3.7 84.6 1.0 CA D:CYS72 4.0 84.6 1.0 N D:CYS75 4.1 80.8 1.0 CA D:CYS33 4.1 90.5 1.0 CA D:CYS75 4.2 80.8 1.0 CB D:ILE32 4.5 81.7 1.0 C D:CYS72 4.6 84.6 1.0 O D:CYS72 4.7 84.6 1.0 CA D:CYS30 4.8 93.8 1.0 C D:ILE32 4.8 81.7 1.0 C D:CYS33 4.8 90.5 1.0 N D:ILE32 4.9 81.7 1.0 C D:TYR71 4.9 78.8 1.0 CA D:ILE32 5.0 81.7 1.0

Zinc binding site 3 out of 5 in the Structure of the U2 5' Module of the A3'-Ssa Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of the U2 5' Module of the A3'-Ssa Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1404 b:129.3 occ:1.00 SG D:CYS23 2.3 106.1 1.0 SG D:CYS58 2.3 109.3 1.0 SG D:CYS61 2.3 114.8 1.0 CB D:CYS23 3.2 106.1 1.0 CB D:CYS61 3.2 114.8 1.0 CB D:CYS58 3.3 109.3 1.0 N D:CYS61 3.6 114.8 1.0 SG D:CYS26 3.8 112.2 1.0 N D:CYS23 4.0 106.1 1.0 CA D:CYS61 4.0 114.8 1.0 CA D:CYS23 4.2 106.1 1.0 CB D:ILE60 4.3 100.3 1.0 C D:ILE60 4.5 100.3 1.0 C23 D:SJT1401 4.6 110.8 1.0 CB D:CYS26 4.7 112.2 1.0 CA D:CYS58 4.7 109.3 1.0 CA D:ILE60 4.8 100.3 1.0 N D:ILE60 4.8 100.3 1.0 C D:CYS61 4.9 114.8 1.0 CG1 D:ILE60 4.9 100.3 1.0

Zinc binding site 4 out of 5 in the Structure of the U2 5' Module of the A3'-Ssa Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of the U2 5' Module of the A3'-Ssa Complex within 5.0Å range: probe atom residue distance (Å) B Occ M:Zn501 b:197.7 occ:1.00 NE2 M:HIS72 2.0 201.5 1.0 ND1 M:HIS78 2.0 179.7 1.0 SG M:CYS59 2.3 166.7 1.0 SG M:CYS56 2.3 166.3 1.0 CE1 M:HIS78 2.4 179.7 1.0 CD2 M:HIS72 2.5 201.5 1.0 CB M:CYS59 3.1 166.7 1.0 CB M:CYS56 3.1 166.3 1.0 CE1 M:HIS72 3.2 201.5 1.0 CG M:HIS78 3.3 179.7 1.0 NE2 M:HIS78 3.7 179.7 1.0 CG M:HIS72 3.7 201.5 1.0 OG1 M:THR61 3.8 173.4 1.0 N M:CYS59 4.0 166.7 1.0 ND1 M:HIS72 4.1 201.5 1.0 CB M:HIS78 4.1 179.7 1.0 CD2 M:HIS78 4.1 179.7 1.0 CA M:CYS59 4.2 166.7 1.0 CE1 M:TYR69 4.2 185.6 1.0 CA M:CYS56 4.5 166.3 1.0 CA M:HIS78 4.7 179.7 1.0 NE2 M:HIS63 4.7 184.6 1.0 CD1 M:TYR69 4.8 185.6 1.0 CB M:LEU58 4.9 162.5 1.0 C M:LEU58 4.9 162.5 1.0 C M:CYS56 5.0 166.3 1.0

Zinc binding site 5 out of 5 in the Structure of the U2 5' Module of the A3'-Ssa Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of the U2 5' Module of the A3'-Ssa Complex within 5.0Å range: probe atom residue distance (Å) B Occ N:Zn601 b:167.9 occ:1.00 NE2 N:HIS425 2.0 137.0 1.0 ND1 N:HIS431 2.0 146.2 1.0 SG N:CYS408 2.3 140.0 1.0 SG N:CYS411 2.3 146.6 1.0 CD2 N:HIS425 2.5 137.0 1.0 CE1 N:HIS431 2.6 146.2 1.0 CB N:CYS408 3.0 140.0 1.0 CE1 N:HIS425 3.3 137.0 1.0 CG N:HIS431 3.3 146.2 1.0 CB N:CYS411 3.3 146.6 1.0 CG N:HIS425 3.8 137.0 1.0 NE2 N:HIS431 3.8 146.2 1.0 CB N:HIS431 3.9 146.2 1.0 N N:CYS411 4.0 146.6 1.0 ND1 N:HIS425 4.1 137.0 1.0 CD2 N:HIS431 4.2 146.2 1.0 CA N:CYS411 4.2 146.6 1.0 CE2 N:TYR416 4.2 139.8 1.0 CA N:CYS408 4.5 140.0 1.0 CA N:HIS431 4.6 146.2 1.0 CE1 N:PHE426 4.6 135.9 1.0 C N:ILE410 4.8 144.2 1.0 CD1 N:PHE426 4.8 135.9 1.0 OH N:TYR416 4.9 139.8 1.0 CB N:ILE410 4.9 144.2 1.0 CZ N:TYR416 5.0 139.8 1.0 CD2 N:TYR416 5.0 139.8 1.0 C N:CYS408 5.0 140.0 1.0

C.Cretu, P.Gee, X.Liu, A.Agrawal, T.V.Nguyen, A.K.Ghosh, A.Cook, M.Jurica, N.A.Larsen, V.Pena. Structural Basis of Intron Selection By U2 Snrnp in the Presence of Covalent Inhibitors. Nat Commun V. 12 4491 2021.
ISSN: ESSN 2041-1723
PubMed: 34301950
DOI: 10.1038/S41467-021-24741-1