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Zinc in PDB 7joc: Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)AdamantanecarboxamideEnzymatic activity of Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide
All present enzymatic activity of Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide, PDB code: 7joc
was solved by
J.T.Andring,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide
(pdb code 7joc). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide, PDB code: 7joc: Zinc binding site 1 out of 1 in 7jocGo back to Zinc Binding Sites List in 7joc
Zinc binding site 1 out
of 1 in the Carbonic Anhydrase IX Mimic Complexed with N-(5-Sulfamoyl-1,3,4- Thiadiazol-2-Yl)Adamantanecarboxamide
Mono view Stereo pair view
Reference:
J.T.Andring,
M.Fouch,
S.Akocak,
A.Angeli,
C.T.Supuran,
M.A.Ilies,
R.Mckenna.
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. J.Med.Chem. V. 63 13064 2020.
Page generated: Tue Oct 29 21:02:24 2024
ISSN: ISSN 0022-2623 PubMed: 33085484 DOI: 10.1021/ACS.JMEDCHEM.0C01390 |
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