Zinc in PDB 7f98: Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95

All present enzymatic activity of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95:
6.1.1.15; 6.1.1.17;

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95, PDB code: 7f98 was solved by N.Malhotra, Y.Manickam, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.94 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.72, 106.11, 145.29, 90, 90, 90
R / Rfree (%)	19 / 23.5

The structure of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Calcium	(Ca)	9 atoms

The binding sites of Zinc atom in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 (pdb code 7f98). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95, PDB code: 7f98:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1902 b:45.5 occ:0.84 SG A:CYS1497 2.3 56.7 1.0 SG A:CYS1453 2.3 49.4 1.0 SG A:CYS1448 2.4 52.0 1.0 SG A:CYS1495 2.4 51.1 1.0 CB A:CYS1497 2.9 56.4 1.0 CB A:CYS1453 3.2 49.8 1.0 CB A:CYS1448 3.3 53.2 1.0 CB A:CYS1495 3.3 48.8 1.0 N A:CYS1497 4.0 53.8 1.0 N A:CYS1448 4.0 44.3 1.0 CA A:CYS1497 4.0 55.7 1.0 OD1 A:ASN1500 4.2 62.8 1.0 CA A:CYS1448 4.3 53.8 1.0 CE1 A:PHE1447 4.4 47.4 1.0 CD1 A:PHE1447 4.4 42.6 1.0 CA A:CYS1453 4.7 44.5 1.0 CA A:CYS1495 4.8 46.7 1.0 CB A:ASN1500 4.8 53.1 1.0 CG A:ASN1500 4.9 57.9 1.0 C A:CYS1497 5.0 59.8 1.0

Zinc binding site 2 out of 2 in the Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Homo Sapiens Prolyl-Trna Synthetase (Hsprs) in Complex with L-Proline and Compound L95 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1902 b:71.7 occ:0.68 SG B:CYS1453 2.3 76.5 1.0 SG B:CYS1448 2.4 88.4 1.0 SG B:CYS1495 2.5 76.1 0.7 SG B:CYS1497 2.6 91.7 1.0 CB B:CYS1448 3.1 88.9 1.0 CB B:CYS1497 3.1 92.5 1.0 CB B:CYS1453 3.2 73.9 1.0 CB B:CYS1495 3.5 74.0 0.7 N B:CYS1448 3.9 73.7 1.0 N B:CYS1497 4.1 97.0 1.0 CA B:CYS1448 4.1 79.6 1.0 CA B:CYS1497 4.3 95.8 1.0 CE1 B:PHE1447 4.3 68.9 1.0 CD1 B:PHE1447 4.4 72.0 1.0 CA B:CYS1453 4.7 75.3 1.0 CA B:CYS1495 4.9 78.4 1.0 C B:CYS1448 4.9 76.2 1.0

N.Malhotra, Y.Manickam, A.Sharma. Hsprs with Atp Binding Pocket Inhibitor To Be Published.