Zinc in PDB 7f4e: Crystal Structure of HST2 in Complex with H3K9BZ Peptide

All present enzymatic activity of Crystal Structure of HST2 in Complex with H3K9BZ Peptide:
2.3.1.286;

The structure of Crystal Structure of HST2 in Complex with H3K9BZ Peptide, PDB code: 7f4e was solved by D.Wang, F.Yan, Y.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.61 / 1.78
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	42.15, 68.402, 94.511, 90, 90, 90
R / Rfree (%)	18.4 / 21.6

The binding sites of Zinc atom in the Crystal Structure of HST2 in Complex with H3K9BZ Peptide (pdb code 7f4e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of HST2 in Complex with H3K9BZ Peptide, PDB code: 7f4e:

Zinc binding site 1 out of 1 in the Crystal Structure of HST2 in Complex with H3K9BZ Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of HST2 in Complex with H3K9BZ Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:30.8 occ:1.00 SG A:CYS170 2.3 27.2 1.0 SG A:CYS146 2.3 78.9 1.0 SG A:CYS143 2.3 24.9 1.0 SG A:CYS173 2.3 32.7 1.0 CB A:CYS146 2.6 23.1 1.0 CB A:CYS170 3.0 25.1 1.0 CB A:CYS143 3.1 24.1 1.0 N A:CYS146 3.2 41.3 1.0 CA A:CYS146 3.5 44.9 1.0 CB A:CYS173 3.5 32.6 1.0 N A:CYS173 3.9 38.4 1.0 CA A:CYS173 4.2 30.6 1.0 C A:GLY145 4.4 43.3 1.0 CA A:CYS170 4.5 25.9 1.0 CA A:CYS143 4.6 19.3 1.0 CB A:VAL172 4.6 32.2 1.0 C A:CYS146 4.6 40.7 1.0 C A:CYS173 4.7 43.4 1.0 N A:GLY174 4.7 44.5 1.0 O A:HOH1000 4.8 42.6 1.0 CA A:GLY145 4.8 41.9 1.0 N A:GLU175 4.8 33.0 1.0 CB A:LYS148 4.8 25.0 1.0 N A:GLY147 4.9 24.1 1.0 N A:GLY145 4.9 26.0 1.0 C A:VAL172 4.9 42.7 1.0 CB A:GLU175 5.0 27.2 1.0

D.Wang, F.Yan, P.Wu, K.Ge, M.Li, T.Li, Y.Gao, C.Peng, Y.Chen. Global Profiling of Regulatory Elements in the Histone Benzoylation Pathway. Nat Commun V. 13 1369 2022.
ISSN: ESSN 2041-1723
PubMed: 35296687
DOI: 10.1038/S41467-022-29057-2