Zinc in PDB 7f0j: Cryoem Structure of Human KV4.2

The binding sites of Zinc atom in the Cryoem Structure of Human KV4.2 (pdb code 7f0j). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Cryoem Structure of Human KV4.2, PDB code: 7f0j:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Cryoem Structure of Human KV4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryoem Structure of Human KV4.2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:55.2 occ:1.00 ND1 B:HIS105 2.1 37.1 1.0 SG H:CYS111 2.3 42.0 1.0 SG B:CYS132 2.3 41.3 1.0 SG B:CYS133 2.3 40.7 1.0 CE1 B:HIS105 2.5 37.1 1.0 CG B:HIS105 3.4 37.1 1.0 CB H:CYS111 3.5 42.0 1.0 NE2 B:HIS105 3.8 37.1 1.0 CB B:CYS133 3.8 40.7 1.0 N B:CYS133 3.8 40.7 1.0 CB B:CYS132 3.9 41.3 1.0 CB B:HIS105 4.1 37.1 1.0 CD2 B:HIS105 4.2 37.1 1.0 C B:CYS132 4.4 41.3 1.0 CA B:CYS133 4.4 40.7 1.0 CA B:HIS105 4.5 37.1 1.0 CB H:SER113 4.5 39.8 1.0 OG H:SER113 4.6 39.8 1.0 CA B:CYS132 4.6 41.3 1.0 CA H:CYS111 4.7 42.0 1.0 N B:CYS132 4.8 41.3 1.0

Zinc binding site 2 out of 4 in the Cryoem Structure of Human KV4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryoem Structure of Human KV4.2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn701 b:55.8 occ:1.00 ND1 C:HIS105 2.1 37.2 1.0 SG B:CYS111 2.3 42.2 1.0 SG C:CYS132 2.3 41.3 1.0 SG C:CYS133 2.3 40.7 1.0 CE1 C:HIS105 2.5 37.2 1.0 CG C:HIS105 3.4 37.2 1.0 CB B:CYS111 3.5 42.2 1.0 NE2 C:HIS105 3.8 37.2 1.0 CB C:CYS133 3.8 40.7 1.0 N C:CYS133 3.8 40.7 1.0 CB C:CYS132 3.9 41.3 1.0 CB C:HIS105 4.1 37.2 1.0 CD2 C:HIS105 4.2 37.2 1.0 C C:CYS132 4.4 41.3 1.0 CA C:CYS133 4.4 40.7 1.0 CA C:HIS105 4.5 37.2 1.0 CB B:SER113 4.5 40.0 1.0 OG B:SER113 4.6 40.0 1.0 CA C:CYS132 4.6 41.3 1.0 CA B:CYS111 4.7 42.2 1.0 N C:CYS132 4.8 41.3 1.0

Zinc binding site 3 out of 4 in the Cryoem Structure of Human KV4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryoem Structure of Human KV4.2 within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn701 b:56.1 occ:1.00 ND1 F:HIS105 2.1 37.2 1.0 SG C:CYS111 2.3 42.3 1.0 SG F:CYS132 2.3 41.2 1.0 SG F:CYS133 2.3 40.6 1.0 CE1 F:HIS105 2.5 37.2 1.0 CG F:HIS105 3.4 37.2 1.0 CB C:CYS111 3.5 42.3 1.0 NE2 F:HIS105 3.8 37.2 1.0 CB F:CYS133 3.8 40.6 1.0 N F:CYS133 3.8 40.6 1.0 CB F:CYS132 3.9 41.2 1.0 CB F:HIS105 4.1 37.2 1.0 CD2 F:HIS105 4.2 37.2 1.0 C F:CYS132 4.4 41.2 1.0 CA F:CYS133 4.4 40.6 1.0 CA F:HIS105 4.5 37.2 1.0 CB C:SER113 4.5 39.9 1.0 OG C:SER113 4.6 39.9 1.0 CA F:CYS132 4.6 41.2 1.0 CA C:CYS111 4.7 42.3 1.0 N F:CYS132 4.8 41.2 1.0

Zinc binding site 4 out of 4 in the Cryoem Structure of Human KV4.2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryoem Structure of Human KV4.2 within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn701 b:55.6 occ:1.00 ND1 H:HIS105 2.1 37.0 1.0 SG F:CYS111 2.3 42.2 1.0 SG H:CYS132 2.3 41.2 1.0 SG H:CYS133 2.3 40.5 1.0 CE1 H:HIS105 2.5 37.0 1.0 CG H:HIS105 3.4 37.0 1.0 CB F:CYS111 3.5 42.2 1.0 NE2 H:HIS105 3.8 37.0 1.0 CB H:CYS133 3.8 40.5 1.0 N H:CYS133 3.8 40.5 1.0 CB H:CYS132 3.9 41.2 1.0 CB H:HIS105 4.1 37.0 1.0 CD2 H:HIS105 4.2 37.0 1.0 C H:CYS132 4.4 41.2 1.0 CA H:CYS133 4.4 40.5 1.0 CA H:HIS105 4.5 37.0 1.0 CB F:SER113 4.5 39.7 1.0 OG F:SER113 4.6 39.7 1.0 CA H:CYS132 4.6 41.2 1.0 CA F:CYS111 4.7 42.2 1.0 N H:CYS132 4.8 41.2 1.0

Y.Kise, G.Kasuya, H.H.Okamoto, D.Yamanouchi, K.Kobayashi, T.Kusakizako, T.Nishizawa, K.Nakajo, O.Nureki. Structural Basis of Gating Modulation of KV4 Channel Complexes. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 34552243
DOI: 10.1038/S41586-021-03935-Z