Zinc in PDB 7ce4: TANKYRASE2 Catalytic Domain in Complex with K-476

Enzymatic activity of TANKYRASE2 Catalytic Domain in Complex with K-476

All present enzymatic activity of TANKYRASE2 Catalytic Domain in Complex with K-476:
2.4.2.30;

Protein crystallography data

The structure of TANKYRASE2 Catalytic Domain in Complex with K-476, PDB code: 7ce4 was solved by Y.Takahashi, M.Suzuki, J.Saito, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.09 / 1.50
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 66.534, 66.534, 116.815, 90, 90, 90
R / Rfree (%) 17.3 / 20.3

Other elements in 7ce4:

The structure of TANKYRASE2 Catalytic Domain in Complex with K-476 also contains other interesting chemical elements:

Fluorine (F) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the TANKYRASE2 Catalytic Domain in Complex with K-476 (pdb code 7ce4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the TANKYRASE2 Catalytic Domain in Complex with K-476, PDB code: 7ce4:

Zinc binding site 1 out of 1 in 7ce4

Go back to Zinc Binding Sites List in 7ce4
Zinc binding site 1 out of 1 in the TANKYRASE2 Catalytic Domain in Complex with K-476


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of TANKYRASE2 Catalytic Domain in Complex with K-476 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1201

b:23.6
occ:1.00
ND1 A:HIS1084 2.1 22.0 1.0
SG A:CYS1081 2.3 23.8 1.0
SG A:CYS1089 2.3 23.8 1.0
SG A:CYS1092 2.4 24.9 1.0
CE1 A:HIS1084 2.9 25.0 1.0
CG A:HIS1084 3.1 27.9 1.0
CB A:CYS1081 3.2 22.1 1.0
CB A:CYS1092 3.3 21.9 1.0
CB A:CYS1089 3.3 20.4 1.0
CB A:HIS1084 3.6 24.1 1.0
N A:HIS1084 3.9 26.6 1.0
N A:CYS1092 3.9 20.9 1.0
NE2 A:HIS1084 4.1 28.0 1.0
CA A:CYS1092 4.2 19.5 1.0
CD2 A:HIS1084 4.2 25.1 1.0
O A:HOH1451 4.2 30.5 1.0
O A:HOH1432 4.3 39.7 1.0
CB A:VAL1083 4.3 30.8 1.0
CA A:HIS1084 4.3 23.7 1.0
CA A:CYS1081 4.6 22.3 1.0
CA A:CYS1089 4.7 20.7 1.0
CB A:ILE1091 4.8 23.6 1.0
C A:VAL1083 4.8 29.4 1.0
CG1 A:VAL1083 4.8 33.0 1.0
N A:VAL1083 4.8 27.9 1.0
CA A:VAL1083 4.9 31.1 1.0
O A:HOH1374 5.0 24.1 1.0

Reference:

H.Kinosada, R.Okada-Iwasaki, K.Kunieda, M.Suzuki-Imaizumi, Y.Takahashi, H.Miyagi, M.Suzuki, K.Motosawa, M.Watanabe, M.Mie, T.Ishii, H.Ishida, J.I.Saito, R.Nakai. The Dual Pocket Binding Novel Tankyrase Inhibitor K-476 Enhances the Efficacy of Immune Checkpoint Inhibitor By Attracting CD8 + T Cells to Tumors. Am J Cancer Res V. 11 264 2021.
ISSN: ISSN 2156-6976
PubMed: 33520373
Page generated: Mon Jul 12 16:58:36 2021

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