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Zinc in PDB 7cbj: Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36Enzymatic activity of Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36
All present enzymatic activity of Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36:
3.1.4.53; Protein crystallography data
The structure of Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36, PDB code: 7cbj
was solved by
X.L.Zhang,
Y.C.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7cbj:
The structure of Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36 also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36
(pdb code 7cbj). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36, PDB code: 7cbj: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 7cbjGo back to![]() ![]()
Zinc binding site 1 out
of 2 in the Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36
![]() Mono view ![]() Stereo pair view
Zinc binding site 2 out of 2 in 7cbjGo back to![]() ![]()
Zinc binding site 2 out
of 2 in the Crystal Structure of PDE4D Catalytic Domain in Complex with Compound 36
![]() Mono view ![]() Stereo pair view
Reference:
R.Zhang,
H.Li,
X.Zhang,
J.Li,
H.Su,
Q.Lu,
G.Dong,
H.Dou,
C.Fan,
Z.Gu,
Q.Mu,
W.Tang,
Y.Xu,
H.Liu.
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinolines Derivatives As Novel, Selective PDE4 Inhibitors For Antipsoriasis Treatment. Eur.J.Med.Chem. V. 211 13004 2021.
Page generated: Mon Jul 12 16:58:37 2021
ISSN: ISSN 0223-5234 PubMed: 33218684 DOI: 10.1016/J.EJMECH.2020.113004 |
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