Zinc in PDB 7bw4: Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2

All present enzymatic activity of Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The binding sites of Zinc atom in the Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2 (pdb code 7bw4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2, PDB code: 7bw4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:74.2 occ:1.00 SG A:CYS301 2.4 59.4 1.0 SG A:CYS306 2.4 53.9 1.0 SG A:CYS310 2.5 51.5 1.0 CB A:CYS301 2.5 59.4 1.0 ND1 A:HIS295 2.5 55.3 1.0 CE1 A:HIS295 3.1 55.3 1.0 CA A:CYS301 3.3 59.4 1.0 O A:CYS306 3.4 53.9 1.0 CB A:CYS306 3.5 53.9 1.0 CG A:HIS295 3.7 55.3 1.0 C A:CYS306 3.8 53.9 1.0 CB A:CYS310 3.8 51.5 1.0 CA A:CYS306 4.1 53.9 1.0 N A:CYS301 4.2 59.4 1.0 CB A:HIS295 4.2 55.3 1.0 NE2 A:HIS295 4.4 55.3 1.0 C A:CYS301 4.4 59.4 1.0 O A:THR293 4.4 61.5 1.0 N A:LEU302 4.5 56.6 1.0 N A:ILE307 4.6 50.4 1.0 N A:HIS295 4.6 55.3 1.0 CD2 A:HIS295 4.6 55.3 1.0 C A:ASN300 4.8 58.1 1.0 O A:ASN300 4.8 58.1 1.0

Zinc binding site 2 out of 2 in the Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:79.0 occ:1.00 ND1 A:HIS642 2.1 61.3 1.0 SG A:CYS487 2.4 71.1 1.0 SG A:CYS646 2.4 67.4 1.0 CE1 A:HIS642 2.4 61.3 1.0 SG A:CYS645 2.5 69.7 1.0 CG A:HIS642 3.0 61.3 1.0 NE2 A:HIS642 3.3 61.3 1.0 CD2 A:HIS642 3.6 61.3 1.0 CB A:HIS642 3.7 61.3 1.0 CB A:CYS645 3.8 69.7 1.0 CE1 A:PHE571 3.9 63.9 1.0 CB A:CYS646 3.9 67.4 1.0 CB A:CYS487 4.0 71.1 1.0 N A:CYS487 4.1 71.1 1.0 CZ A:PHE571 4.2 63.9 1.0 N A:CYS646 4.5 67.4 1.0 CA A:CYS487 4.5 71.1 1.0 C A:CYS645 4.6 69.7 1.0 CD1 A:PHE571 4.7 63.9 1.0 CA A:CYS645 4.8 69.7 1.0 CA A:CYS646 4.8 67.4 1.0 C A:GLY486 4.8 67.0 1.0 CA A:HIS642 4.9 61.3 1.0

Q.Peng, R.Peng, Y.Shi. Structure of the Rna-Dependent Rna Polymerase From Sars-Cov-2 To Be Published.