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Zinc in PDB 7b4f: Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I)

Protein crystallography data

The structure of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I), PDB code: 7b4f was solved by H.Rozenberg, O.Degtjarik, Z.Shakked, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.42 / 1.78
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.21, 49.743, 33.816, 90, 93.36, 90
R / Rfree (%) 15.5 / 19.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I) (pdb code 7b4f). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I), PDB code: 7b4f:

Zinc binding site 1 out of 1 in 7b4f

Go back to Zinc Binding Sites List in 7b4f
Zinc binding site 1 out of 1 in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna: R282W-Mq (I) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:17.3
occ:1.00
ND1 A:HIS179 2.0 16.8 1.0
SG A:CYS242 2.3 14.5 1.0
SG A:CYS238 2.3 15.2 1.0
SG A:CYS176 2.3 15.3 1.0
CE1 A:HIS179 2.9 17.0 1.0
CB A:CYS242 3.1 18.0 1.0
CB A:CYS238 3.1 13.0 1.0
CG A:HIS179 3.1 15.1 1.0
CB A:CYS176 3.3 13.6 1.0
CB A:HIS179 3.5 15.3 1.0
CA A:CYS238 3.7 15.0 1.0
NE2 A:HIS179 4.1 17.1 1.0
N A:CYS176 4.1 13.5 1.0
CD2 A:HIS179 4.2 20.4 1.0
CA A:CYS176 4.3 13.2 1.0
N A:HIS179 4.3 17.0 1.0
O A:MET237 4.4 18.0 1.0
CA A:CYS242 4.5 15.9 1.0
N A:ASN239 4.6 15.9 1.0
CA A:HIS179 4.6 16.4 1.0
C A:CYS238 4.7 16.5 1.0
O A:HOH506 4.7 15.3 1.0
N A:CYS238 4.8 14.2 1.0
O A:CYS176 4.8 18.0 1.0
C A:CYS176 4.9 16.4 1.0

Reference:

O.Degtjarik, D.Golovenko, Y.Diskin-Posner, L.Abrahmsen, H.Rozenberg, Z.Shakked. P53 Structure 9 To Be Published.
Page generated: Fri Dec 17 11:45:58 2021

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