Zinc in PDB 7b4e: Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq

Protein crystallography data

The structure of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq, PDB code: 7b4e was solved by O.Degtjarik, H.Rozenberg, Z.Shakked, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.06 / 1.58
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 136.505, 49.553, 33.401, 90, 93.44, 90
R / Rfree (%) 16.6 / 20.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq (pdb code 7b4e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq, PDB code: 7b4e:

Zinc binding site 1 out of 1 in 7b4e

Go back to Zinc Binding Sites List in 7b4e
Zinc binding site 1 out of 1 in the Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of Reactivation of Oncogenic P53 Mutants By A Small Molecule: Methylene Quinuclidinone (Mq). Human P53DBD-R282W Mutant Bound to Dna and Mq: R282W-Dna-Mq within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:11.7
occ:1.00
ND1 A:HIS179 2.1 11.1 1.0
SG A:CYS238 2.3 11.6 1.0
SG A:CYS176 2.3 11.9 1.0
SG A:CYS242 2.3 12.7 1.0
CE1 A:HIS179 3.0 11.6 1.0
CB A:CYS242 3.1 13.0 1.0
CG A:HIS179 3.1 12.6 1.0
CB A:CYS238 3.2 10.8 1.0
CB A:CYS176 3.3 11.7 1.0
CB A:HIS179 3.5 11.9 1.0
CA A:CYS238 3.7 11.2 1.0
NE2 A:HIS179 4.1 12.6 1.0
N A:CYS176 4.1 11.0 1.0
CD2 A:HIS179 4.2 13.1 1.0
CA A:CYS176 4.3 11.5 1.0
N A:HIS179 4.3 13.4 1.0
O A:MET237 4.4 16.9 1.0
CA A:CYS242 4.5 12.0 1.0
N A:ASN239 4.5 13.4 1.0
CA A:HIS179 4.6 13.2 1.0
C A:CYS238 4.7 11.7 1.0
O A:HOH519 4.8 13.2 1.0
N A:CYS238 4.8 11.8 1.0
C A:CYS176 4.9 11.9 1.0
O A:CYS176 4.9 12.3 1.0
C A:MET237 5.0 15.3 1.0

Reference:

O.Degtjarik, D.Golovenko, Y.Diskin-Posner, L.Abrahmsen, H.Rozenberg, Z.Shakked. P53 Structure 8 To Be Published.
Page generated: Fri Dec 17 11:45:58 2021

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